AU - pourabbas, sara AU - kesmati, mahnaz AU - rasekh, abdolrahman TI - Study of the the anxiolytic effects of fennel and possible roles of both gabaergic system and estrogen receptors in these effects in adult female rat PT - JOURNAL ARTICLE TA - Physiol-Pharmacol JN - Physiol-Pharmacol VO - 15 VI - 1 IP - 1 4099 - http://ppj.phypha.ir/article-1-664-en.html 4100 - http://ppj.phypha.ir/article-1-664-en.pdf SO - Physiol-Pharmacol 1 AB  - Introduction: Fennel is rich in phytoestrogens and is used for estrogen deficiency disorders. Estrogens affect anxiety through neurochemical systems such as GABA-A receptors. In this study the effects of fennel on GABA-A and estrogen receptors in anxiety were investigated. Methods: Adult female Wistar rats weighing (180±20 g) were divided into 8 groups. Groups received saline, fennel (200, 500, 750 mg/kg), tamoxifen (15 mg/kg) + fennel (500 mg/kg), picrotoxin (1 mg/kg) + fennel (500 mg/kg). A control group was also used. Elevated plus maze was used for evaluation of anxiety by measuring the time spent in the open arm. All drugs were administered intraperitoneally. Results: The results showed that fennel only at the dose of 500 mg/kg had significant anxiolytic effects and increased the time spent in open arms (P CP - IRAN IN - Ahvaz-melirah-khiyabane shahid beheshti(mehran)- pelake 58 LG - eng PB - Physiol-Pharmacol PG - 134 PT - Experimental research article YR - 2011