AU - Mohammad-Zadeh, Mohammad AU - Mirnajafi-Zadeh, Javad AU - Fathollahi, Yaghoub AU - Javan, Mohammad AU - Ghorbani, Parviz TI - Effect of low frequency stimulation of perforant path on kindling acquisition and synaptic transmission in the dentate gyrus in rats PT - JOURNAL ARTICLE TA - Physiol-Pharmacol JN - Physiol-Pharmacol VO - 11 VI - 2 IP - 2 4099 - http://ppj.phypha.ir/article-1-238-en.html 4100 - http://ppj.phypha.ir/article-1-238-en.pdf SO - Physiol-Pharmacol 2 AB  - Introduction: Previous studies have been shown that low frequency stimulation (LFS) has an inhibitory effect on kindling acquisition. However, the mechanism of this effect has not been completely determined. In the present study, the effect of LFS of the perforant path on seizures induced by rapid perforant path kindling was investigated. Methods: Animals were kindled by electrical stimulation of perforant path. One group of animals (n=6) received LFS (0.1 ms pulses at 1 Hz, 200 pulse, and 50-150 µA) after termination of each kindling stimulations. In control groups, animals received only kindling stimulations (n=8) or LFS (n=4). Basal field potential recording and paired pulse stimulations were done before kindling stimulations every days. Results: Application of LFS significantly retarded the kindling acquisition and increased the number of stimulations to achieve different seizure stages [F(4,60)=10.9, P CP - IRAN IN - Department of Physiology, School of Medical Sciences, Tarbiat Modares University, Tehran, Iran LG - eng PB - Physiol-Pharmacol PG - 137 PT - Experimental research article YR - 2007