%0 Journal Article %A Hafez-Amini, Parivash %A Shams, Jamal %A Shabahng-Saber-Tehrani, Ali %A Haeri-Rohani, Ali %A Parivar, Kazem %A Babapour, Vahab %A Sahraei, Hedayat %T Olanzapine antagonizes the acquisition and expression of morphine-induced conditioned place preference in male and female mice %J Physiology and Pharmacology %V 10 %N 2 %U http://ppj.phypha.ir/article-1-251-en.html %R %D 2006 %K Morphine; Olanzapine; Place preference; Nitric oxide; Mice., %X Introduction: Several investigations have indicated that dopamine D receptors could influence morphine 2 eward. The influence of olanzapine (a D dopamine receptor antagonist) on the morphine-induced conditioned 2 lace preference (CPP) in male and female mice was investigated in the present study. Methods: The effects of olanzapine on the acquisition and expression of morphine CPP in male and female -MRI mice (W: 20-25 g) were investigated in the present study. Resultd: Subcutaneous (s.c.) injection of morphine (1-10 mg/kg, three drug sessions) induced place preference oth in male and female mice. Intraperitoneal (i.p.) administration of olanzapine (0.5-5 mg/kg) induced place version (CPA) in female mice but not in male mice. Administration of olanzapine (1, 2.5, 5 mg/kg, i.p.) reduced oth the acquisition and expression of morphine-induced CPP in male and female mice. However, olanzapine (5 g/kg, i.p.) caused more than 80% mortality in female but not male mice. The effects of olanzapine were reversed y L-arginine (20 mg/kg, i.p.) pre-administration. Conlusion: We conclude that olanzapine reduced morphine effects via different mechanism/s. %> http://ppj.phypha.ir/article-1-251-en.pdf %P 135-142 %& 135 %! %9 Experimental research article %L A-10-74-3 %+ %G eng %@ 24765236 %[ 2006