TY - JOUR JF - Physiol-Pharmacol JO - Physiol Pharmacol VL - 16 IS - 1 PY - 2012 Y1 - 2012/4/01 TI - Alterations in dopamine related behavior of the offspring of pregnant Wistar rats exposed to noise pollution stress TT - تغییر در رفتارهای وابسته به دوپامین در فرزندان موشهای ویستار باردار مواجه شده با استرس آلودگی صوتی N2 - Introduction: Effects of stress on nervous system activity and development are well defined. In the present study, the effects of maternal stress on dopamine-related behavior in the offspring were studied. Methods: Female pregnant Wistar rats (200 g) were randomly exposed to the noise pollution stress (125 db) for 14 days (5 min/day). The time of exposure was random in order to avoid adaptation. The offspring were nursed by their mothers until the adolescence (200 g-3 mounts of age). These animals were examined for their seeking behavior including rearing, sniffing and locomotion using open field method. Twenty four hours later, they received subcutaneous administration of the dopamine D2 receptor antagonist, sulpiride (5 mg/kg) for evaluation of dopamine receptor sensitization. Results: Our results showed that sniffing was reduced (P SP - 79 EP - 85 AU - Hassanvand, Tayebeh AU - Balooch, Mohammad AU - Azarnia, Mahnaz AU - Zardooz, Homeira AU - Erfani, Marjan AU - Hosseini, Seyedeh Yassaman AU - Sahraei, Hedayat AD - KW - Noise Pollution Stress KW - D2 Dopamine Receptors KW - Sniffing KW - Rearing KW - Locomotion UR - http://ppj.phypha.ir/article-1-805-en.html ER -