%0 Journal Article %A Hafazeh, Leila %A Changizi-Ashtiyani, Saeed %A Najafi, Houshang %A Ghasemi, Faezeh %A Rahjoo, Tina %A Babaei, Saeid %A Ramezani, Majid %T Therapeutic effects of adipose-derived mesenchymal stem cells on gentamicin-induced renal failure %J Physiology and Pharmacology %V 24 %N 2 %U http://ppj.phypha.ir/article-1-1527-en.html %R 10.32598/ppj.24.2.30 %D 2020 %K Acute renal failure, Gentamicin, Mesenchymal stem cells, Oxidative stress., %X Introduction: Considering the limitations of conventional therapeutic methods in renal failure, researchers are paying attention to the application of adipose-derived mesenchymal stem cells (AD-MSCs) and their protective effects against acute renal failure. This study aims to assess the therapeutic effects of AD-MSCs in gentamicin-induced renal failure in rats. Methods: In this study, 40 male Wistar rats were studied in control, sham, gentamicin treated with and without receiving AD-MSCs. After 10 days, blood samples were collected and hemodynamic parameters, malondialdehyde and ferric reducing antioxidant power (FRAP) measured in the right and left kidneys underwent histologic examination. Results: Gentamicin administration significantly increased plasma creatinine, blood urea nitrogen, oxidative stress parameters and histologic damages; while significantly reduced FRAP in the gentamicin-receiving group in comparison with the sham group. AD-MSCs treatment significantly improved renal function parameters, oxidative stress and histologic damages in comparison with the gentamicin receiving group. Conclusion: Intravenous injection of AD-MSCs in gentamicin-induced renal failure improved renal function, oxidative stress parameters and histologic damages. %> http://ppj.phypha.ir/article-1-1527-en.pdf %P 133-141 %& 133 %! Stem cells and gentamicin nephrotoxicity %9 Experimental research article %L A-10-963-7 %+ Department of Internal Medicine, School of Medicine, Bagiatallah University of Medical Sciences, Tehran, Iran %G eng %@ 24765236 %[ 2020