TY - JOUR T1 - Effect of inhalation alcoholic extract of Peganum harmala on induction of Anxiety like behavior in Elevated Plus-Maze TT - JF - Physiol-Pharmacol JO - Physiol-Pharmacol VL - 11 IS - 2 UR - http://ppj.phypha.ir/article-1-60-en.html Y1 - 2007 SP - 153 EP - 159 KW - Peganum harmala KW - Fear KW - Harmaline KW - Inhalation KW - Elevated Plus-Maze N2 - Based on the extensive application of Peganum harmala (P.h) seeds in the Asian traditional medicine, we tried to investigate its possible anxiety effect. Method: The effect of P.h. extract inhalation was evaluated in adult male rats using elevated plus-maze apparatus. The humidity of prepared ethanol extract was 37%. Animals in different groups (n=6) received 2, 4, 6, 12 or 18 gr/ml doses of the extract using Nebulizer. harmaline drug (0.13 gr/ml) was used as positive control drug. Results: Compared with saline treated group, harmaline as the positive control significantly caused fear in rats as it was shown by increased time spent in closed arm of plus-maze (p< 0.05). Also, ethanol extract of P.h was able to show anxiety effect at doses 6, 12 and 18 mg/ml (p M3 ER -