%0 Journal Article %A Peyvandi, Ali Asghar %A Niknazar, Somayeh %A Zare Mehrjerdi, Fatemeh %A Abbaszadeh, Hojjat-Allah %A Khoshsirat, Shahrokh %A Peyvandi, Maryam %T Molecular mechanisms and signaling pathways involved in immunopathological events of COVID-19 %J Physiology and Pharmacology %V 25 %N 3 %U http://ppj.phypha.ir/article-1-1789-en.html %R 10.52547/ppj.25.3.193 %D 2021 %K SARS-CoV-2 Infection, Signal transduction pathways, Cytokine storm., %X Introduction: COVID-19, a novel coronavirus that causes severe acute respiratory syndrome (SARS-CoV-2), is currently regarded as the most serious viral disease. During corona infection, viruses bind to host proteins and employ a variety of cellular pathways for their own purposes. Cell signaling is important for the regulation of cellular function. SARS-CoV-2 infection alters multiple signal transduction pathways that are critical for cell survival. The virus causes a severe and prolonged period of hypercytokinemia with misusing of these signaling cascades. Hyperactivation of the host immune system after infection with SARS-CoV-2 is the main cause of death in COVID-19 patients. Thus, to develop effective therapeutic approaches, it is necessary to first understand the problem and the underlying molecular pathways implicated in host immunological function/dysfunction. A number of intracellular signaling cascades have been implicated in infected cell pathways, including MAPK pathway, NF-κB pathway, JAK–STAT signaling pathway, PI3K/AKT/mTOR pathway and TLRI signaling cascades. Here, we have presented the molecular insights on the potential mechanisms involved in immunopathological events of COVID-19. %> http://ppj.phypha.ir/article-1-1789-en.pdf %P 193-205 %& 193 %! Molecular Biology of COVID-19 %9 Review %L A-11-1299-2 %+ Hearing Disorders Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran %G eng %@ 24765236 %[ 2021