Physiology and Pharmacology
Physiol Pharmacol
Medical Sciences
http://ppj.phypha.ir
32
journal32
24765236
24765244
10.61186/phypha
(previous ISSN: 17350581)
en
jalali
1393
10
1
gregorian
2015
1
1
18
4
online
1
fulltext
en
تاثیر تمرینات ورزشی و مکمل ال- آرژنین بر فشار اکسایشی و عملکرد بطن چپ در موش های با انفارکتوس قلبی
Effect of exercise training and L-arginine supplementation on oxidative stress and left ventricular function in rats with myocardial infarction
Cardiovascular Physiology/Pharmacology
Cardiovascular Physiology/Pharmacology
Experimental research article
Experimental research article
Introduction: The aim of the present study was to evaluate the effect of exercise training and L-arginine
supplementation on oxidative stress and systolic ventricular function in rats with myocardial infarction (MI).
Methods: Four weeks after the surgically-induced MI, 40 male Wistar rats were randomly assigned to the following
4 groups (n=10): MI-sedentary control (Sed) MI-exercise (Ex) MI-sedentary+L-arginine (Sed+LA) and MIexercise+
L-arginine (Ex+LA). The Ex and Ex+LA groups ran for 10 weeks on treadmill. Rats in the L-arginine-treated
groups drank water containing 4% L-arginine. Before and after the training program, all subjects underwent resting
echocardiography. Also catalase, glutathione peroxidase, malondialdehyde and myeloperoxidase were measured.
Results: cardiac output, stroke volume and fractional shortening in Ex and Ex+LA groups were significantly
increased compared to the Sed group. Cardiac systolic function in Ex+LA group was significantly greater than in Ex
group. Infarct size was insignificantly reduced in response to exercise. Also, glutathione peroxidase activity was
increased while malondialdehyde showed a decrease in response to exercise training, but no effect on myeloperoxidase
and catalase was noted. There was no difference in enzyme activity between the training groups.
Conclusion: Exercise training increased LV systolic function by decreasing oxidative stress and increasing
antioxidant defense system in rats with myocardial infarction. It appears that L-arginine improves left ventricular
function, but has no effect on oxidative stress indices.
Exercise training, L-arginine, Oxidative Stress, Myocardial Infarction
445
454
http://ppj.phypha.ir/browse.php?a_code=A-10-465-2&slc_lang=en&sid=1
Kamal
Ranjbar
کمال
رنجبر
kamal_ranjbar2010@yahoo.com
3200319475328460014950
3200319475328460014950
No
Dept. of Sport Physiology, Faculty of Physical Education and Sport Sciences, Bu-Ali Sina University, Hamedan, Iran
Afshin
Nazari
افشین
نظری
nazary125@yahoo.com
3200319475328460014951
3200319475328460014951
No
Dept. of Physiology, Razi Herbal Medicine Research Center, Lorestan University of Medical Sciences, Khoramabad, Iran
Farzad
Nazem
فرزاد
ناظم
farzadnazen1@ycahoo.com
3200319475328460014952
3200319475328460014952
Yes
Dept. of Sport Physiology, Faculty of Physical Education and Sport Sciences, Bu-Ali Sina University, Hamedan, Iran