Physiology and Pharmacology
Physiol Pharmacol
Medical Sciences
http://ppj.phypha.ir
32
journal32
24765236
24765244
10.61186/phypha
(previous ISSN: 17350581)
en
jalali
1393
10
1
gregorian
2015
1
1
18
4
online
1
fulltext
en
اثر بلوکر گیرنده Mas (A779) و فشار پرفیوژن کلیوی بر غلظت نیتریت در غیاب رسپتورهای1&2 آنژیوتانسینII در رت های نر و ماده
The effects of Mas receptor antagonist (A779) and renal perfusion pressure on serum nitrite concentration in male and female rats when angiotensin II receptors 1 & 2 were blocked
Renal Physiology/Pharmacology
Renal Physiology/Pharmacology
Experimental research article
Experimental research article
Introduction: Renin angiotensin system has an important role in blood pressure and renal functions. Active
angiotensin-converting enzyme 2 converts angiotensin I into angiotensin-(1-7) which is a vasodilator hormone and
interacts with nitric oxide changes as well as other angiotensin II receptors. In this study we evaluated the role of Mas
receptor antagonist (A779) and renal perfusion pressure (RPP) on serum nitric oxide metabolite (nitrite) concentration
when angiotensin II receptors (AT1R & AT2R) were blocked.
Methods: After angiotensin II receptors blockage in anesthetized male and female rats, RPP was maintained at two
levels 80 & 100 mmHg by occluder around aorta above the renal arteries, and the effects of placebo and A779 on
concentration of serum nitrite level were studied.
Results: The results showed that when angiotensin II receptors were blocked, the serum level of nitrite in both
sexes, was not dependent on angiotensin-(1-7) receptor and did not change statistically, but by increasing renal
perfusion pressure and in the presence of angiotensin-(1-7) receptor the serum level of nitrite increased significantly
(p<0.05) in male rats but not in female rats.
Conclusion: Using angiotensin II receptors blockades and by increase of RPP, the serum level of nitrite is sexrelated.
This study showed the importance of Mas receptor in male sex when AT1R & AT2R were blocked.
Angiotensin (1-7),Mas receptor, Angiotensin II receptors, NO
437
444
http://ppj.phypha.ir/browse.php?a_code=A-10-788-1&slc_lang=en&sid=1
Azam
Mansoori
اعظم
منصوری
azam.mansoori7@yahoo.com
3200319475328460014947
3200319475328460014947
No
Water & Electrolytes Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
shahrebanoo
oryan
شهربانو
عریان
sh_oryan@yahoo.com
3200319475328460014948
3200319475328460014948
No
Dept. of Biology, University of Kharazmi, Tehran, Iran
Mehdi
nematbakhsh
مهدی
نعمت بخش
nematbakhsh@med.mui.ac.ir
3200319475328460014949
3200319475328460014949
Yes
Water & Electrolytes Research Center, Isfahan University of Medical Sciences, Isfahan, Iran