Physiology and Pharmacology
Physiol Pharmacol
Medical Sciences
http://ppj.phypha.ir
32
journal32
24765236
24765244
10.61186/phypha
(previous ISSN: 17350581)
en
jalali
1394
2
1
gregorian
2015
5
1
19
2
online
1
fulltext
en
Lithium-based antioxidants: electrochemical properties and influence on immune cells
Pharmacokinetics/Dynamics
Pharmacokinetics/Dynamics
Experimental research article
Experimental research article
Introduction: Lithium salts are known as effective psychotropic medicine for treatment bipolar disorder and may be used to treat alcoholism, schizoaffective disorders, and cluster headaches. The antioxidant activity and immunomodulatory effects of prospective lithium compounds have been investigated in this work.
Materials and Methods: The antioxidant properties were studied by the voltammetry method. Influence of the lithium compounds on the immune cells of human blood were determined by measuring phagocytic activity of leucocytes and by the rate of blastic transformation of lymphocytes.
Results: Relatively better antioxidant and immunotropic properties have been revealed for lithium ascorbate, compare to widely used drug-lithium carbonate. Lithium aspartate revealed antioxidant activity, as well.
Conclusion: Studied lithium salts can be considered as prospective psychotropic antioxidant with immunomodulatory effects. The combination of these properties significantly extends the potential medical applications of lithium salts.
antioxidant activity, immunomodulatory effects, voltammetry, lithium ascorbate, lithium aspartate
107
113
http://ppj.phypha.ir/browse.php?a_code=A-10-846-1&slc_lang=en&sid=1
Evgenii
Plotnikov
plotnikov.e@mail.ru
3200319475328460015284
3200319475328460015284
Yes
Elena
Korotkova
eikor@mail.ru
3200319475328460015285
3200319475328460015285
No
Olesya
Voronova
oaa@mail.ru
3200319475328460015286
3200319475328460015286
No
Elena
Dorozhko
evd@mail.ru
3200319475328460015287
3200319475328460015287
No
Nikolay
Bohan
bna909@gmail.com
3200319475328460015288
3200319475328460015288
No
Sergey
Plotnikov
plotnikov.sv33@mail.ru
3200319475328460015289
3200319475328460015289
No