Physiology and Pharmacology
Physiol Pharmacol
Medical Sciences
http://ppj.phypha.ir
32
journal32
24765236
24765244
10.61186/phypha
(previous ISSN: 17350581)
en
jalali
1394
11
1
gregorian
2016
2
1
20
1
online
1
fulltext
en
Low pH preconditioned amniotic epithelial cells for stem cell therapy of cancer
Cell, Stem Cell and Cancer
Cell, Stem Cell and Cancer
Letter to the editor
Letter to the editor
<p dir="ltr" style="margin: 0in 0in 0pt; line-height: 200%; text-align: justify;"><span style="font-size:12px;">Amniotic epithelial cells (AECs) possess unique characteristics, which make them a suitable source for cell-based therapeutic strategies. AECs have stem cell properties with low-immunogenicity (due to expressing HLA-G molecule and absence of MHC class I and II antigens) and no ethical problems, as well as availability in sufficient numbers, which can be obtained from a placenta. We have recently shown that the AECs have anti-cancer properties due to inhibition of angiogenesis, induction of apoptosis and cell cycle arrest probably through inhibition of HSP90. Since the viability of AECs must be improved after in vivo administration in acidic microenvironment of tumor, we clarify here that low pH preconditioning of AECs would lead to more survival of implanted cells in tumor site as well as improved functional outcomes.</span></p>
Amniotic membrane, Epithelial cells, Preconditioning, Cancer, Stem cell therapy.
1
4
http://ppj.phypha.ir/browse.php?a_code=A-12-666-3&slc_lang=en&sid=1
Hassan
Niknejad
niknejad@sbmu.ac.ir
3200319475328460016162
3200319475328460016162
Yes
Department of Tissue Engineering and Regenerative Medicine, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Ghasem
Yazdanpanah
gh.yazdnpnha69@gmail.com
3200319475328460016163
3200319475328460016163
No
Department of Tissue Engineering and Regenerative Medicine, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Mona
Kakavand
mkaka5426954@yahoo.com
3200319475328460016164
3200319475328460016164
No
Nanomedicine and Tissue Engineering Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Yasaman
Lavaie
Yasaman_jasmine54215@yahoo.com
3200319475328460016165
3200319475328460016165
No
Nanomedicine and Tissue Engineering Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran