Physiology and Pharmacology
Physiol Pharmacol
Medical Sciences
http://ppj.phypha.ir
32
journal32
24765236
24765244
10.61186/phypha
(previous ISSN: 17350581)
en
jalali
1395
11
1
gregorian
2017
2
1
21
1
online
1
fulltext
en
Olive leaf extract reverses the behavioral disruption and oxidative stress induced by intrastriatal injection of 6-hydroxydopamine in rats
Neurophysiology/Pharmacology
Neurophysiology/Pharmacology
Experimental research article
Experimental research article
<p dir="ltr" style="text-align: justify;"><span style="font-size: 12px;"><b>Introduction: </b><font face="Arial,Arial"><font face="Arial,Arial">Oxidative stress seems to play a critical role in the degeneration of dopaminergic neurons in Parkinson’s disease (PD). Antioxidant compounds can deactivate and scavenge free radical. Olive leaves are considered as a useful source of phenolic compounds. Therefore, this study was designed to investigate the effects of methanolic olive leaf extract (OLE) on neurobehavioral activity and antioxidant enzyme activity, malondialdehyde (MDA) and glutathione (GSH) levels in striatum of rats in an experimental model of PD. </font></font></span><span style="font-size: 12px;"><b>Methods: </b><font face="Arial,Arial"><font face="Arial,Arial">The PD was induced in animals by intrastriatal injection of 6-hydroxydopamin unilaterally. Animals were pretreated with the OLE (50, 100 and 150 mg/kg body weight) for 7 weeks, and then behavioral activity (narrow beam and grip testes) and antioxidant parameters were evaluated. </font></font></span><span style="font-size: 12px;"><b>Results: </b><font face="Arial,Arial"><font face="Arial,Arial">In our study behavioral testes showed improvement in motor coordination and balance behavior in rats pretreated with OLE. Furthermore the extract of olive leaf restored the activity of antioxidant enzymes (superoxide dismutase, glutathione peroxidase, glutathione reductase and catalase) and decreased MDA and increased GSH levels in the brain of rats. </font></font></span><span style="font-size: 12px;"><b>Conclusion: </b><font face="Arial,Arial"><font face="Arial,Arial">Our results suggest that OLE shows a neuroprotective effect in animal models of Parkinson's disease.</font></font></span></p>
Olive leaf extract, Oxidative stress, 6-Hydroxydopamine, Neurobehavioral activity, Parkinson's disease
44
53
http://ppj.phypha.ir/browse.php?a_code=A-10-625-3&slc_lang=en&sid=1
Mahboobeh
Aghagolzadeh
Aghagolzadeh_m@yahoo.com
3200319475328460017332
3200319475328460017332
No
Department of Biology, Faculty of Basic Sciences, University of Mazandaran, Babolsar, Iran
Akbar
hajizadeh Moghaddam
a.hajizadeh@umz.ac.ir
3200319475328460017333
3200319475328460017333
Yes
Department of Biology, Faculty of Basic Sciences, University of Mazandaran, Babolsar, Iran
Bagher
seyedalipour
b.seyedalipour@umz.ac.ir
3200319475328460017334
3200319475328460017334
No
Department of Cellular and Molecular Biology, Faculty of Basic Sciences, University of Mazandaran, Babolsar, Iran