Physiology and Pharmacology
Physiol Pharmacol
Medical Sciences
http://ppj.phypha.ir
32
journal32
24765236
24765244
10.61186/phypha
(previous ISSN: 17350581)
en
jalali
1397
12
1
gregorian
2019
3
1
23
1
online
1
fulltext
en
Antidiabetic effect of hydroethanolic extract of Crocus sativus stigmas, tepals and leaves in streptozotocin-induced diabetic rats
Pharmacokinetics/Dynamics
Pharmacokinetics/Dynamics
Experimental research article
Experimental research article
<div style="text-align: justify;">Introduction: The present study investigated for the first time, the antihyperglycemic effect of tepals and leaves of Crocus sativus in streptozotocin-induced diabetic rats. The effect of these by-products were compared with that of saffron stigma and glibenclamide. Methods: Hydroethanolic extracts (stigmas, tepals and leaves) and glibenclamide were administered orally in aqueous solution daily for 21 days. In the present study, 36 male rats were used. Six rats were used in each group. Group 1: normal control rats (N), received distilled water; group 2: diabetic control rats (D), received distilled water; group 3: treated diabetic rats (TPL), received tepal (TPL) extract; group 4: treated diabetic rats (STG), received stigma (STG) extract; group 5: treated diabetic rats (LF), received leaf (LF) extract and group 6: treated diabetic rats (GLB), received glibenclamide (GLB). Blood glucose, body weight, water intake, urine elimination, plasma triglycerides, cholesterol, urea, creatinine, aspartate amino transferase (AST) and alanine amino transferase (ALT) levels were evaluated. Results: The present data indicated that the tepals and stigmas extracts significantly prevented decreasing body weight and protected against elevation of water intake, urine elimination, blood glucose, plasma triglycerides, cholesterol, urea, creatinine, AST and ALT levels in treated diabetic rats as compared to untreated diabetic rats. Leaves extract significantly prevented decreasing body weight. It decreased water intake, blood glucose, plasma triglycerides, cholesterol, creatinine, AST and ALT. Conclusion: Based on our data, the oral administration of tepals, stigmas and leaves extract of Crocus sativus reduces blood glucose levels and improves control of diabetes complications.</div>
Crocus sativus, Antihyperglycemic effect, Streptozotocine, Saffron, By-products.
9
20
http://ppj.phypha.ir/browse.php?a_code=A-10-998-2&slc_lang=en&sid=1
Sabir
Ouahhoud
s.ouahhoud@ump.ac.ma
3200319475328460029520
3200319475328460029520
Yes
Laboratory of Biochemistry and Biotechnology, Department of Biology, Faculty of Sciences, University Mohamed Premier, Oujda, Morocco
Iliass
Lahmass
i.lahmass@ump.ac.ma
3200319475328460029521
3200319475328460029521
No
Laboratory of Biochemistry and Biotechnology, Department of Biology, Faculty of Sciences, University Mohamed Premier, Oujda, Morocco
Mohamed
Bouhrim
m.bouhrim@ump.ac.ma
3200319475328460029522
3200319475328460029522
No
Laboratory of Physiology, Genetic and Ethnopharmacology, Department of Biology, Faculty of Sciences, University Mohamed Premier, Oujda, Morocco
Amine
Khoulati
a.khoulati@ump.ac.ma
3200319475328460029523
3200319475328460029523
No
Laboratory of Biochemistry and Biotechnology, Department of Biology, Faculty of Sciences, University Mohamed Premier, Oujda, Morocco
Assia
Sabouni
a.sabouni@ump.ac.ma
3200319475328460029524
3200319475328460029524
No
Laboratory of Biochemistry and Biotechnology, Department of Biology, Faculty of Sciences, University Mohamed Premier, Oujda, Morocco
Redouanae
Benabbes
r.benabbes@ump.ac.ma
3200319475328460029525
3200319475328460029525
No
Laboratory of Biochemistry and Biotechnology, Department of Biology, Faculty of Sciences, University Mohamed Premier, Oujda, Morocco
Abdeslam
Asehraou
a.asehraou@ump.ac.ma
3200319475328460029526
3200319475328460029526
No
Laboratory of Biochemistry and Biotechnology, Department of Biology, Faculty of Sciences, University Mohamed Premier, Oujda, Morocco
Mohammed
Choukri
m.choukri@ump.ac.ma
3200319475328460029527
3200319475328460029527
No
Laboratory of Biochemistry, Central Laboratory Service - CHU, Mohammed VI, Faculty of Medicine and Pharmacy, University Mohamed Premier, Oujda, Morocco
Mohamed
Bnouham
m.bnouham@ump.ac.ma
3200319475328460029528
3200319475328460029528
No
Laboratory of Physiology, Genetic and Ethnopharmacology, Department of Biology, Faculty of Sciences, University Mohamed Premier, Oujda, Morocco
Ennouamane
Saalaoui
e.saalaoui@ump.ac.ma
3200319475328460029529
3200319475328460029529
No
Laboratory of Biochemistry and Biotechnology, Department of Biology, Faculty of Sciences, University Mohamed Premier, Oujda, Morocco