Physiology and Pharmacology
Physiol Pharmacol
Medical Sciences
http://ppj.phypha.ir
32
journal32
24765236
24765244
10.61186/phypha
(previous ISSN: 17350581)
en
jalali
1398
4
1
gregorian
2019
7
1
23
2
online
1
fulltext
en
Protective effects of Petroselinum crispum on ischemia/reperfusion-induced acute kidney injury in rats
Renal Physiology/Pharmacology
Renal Physiology/Pharmacology
Experimental research article
Experimental research article
<div style="text-align: justify;"><strong>Introduction: </strong>Petroselinum crispum (P. crispum) is an associate of Umbelliferae family that has several therapeutic attributes. Ischemia/reperfusion (I/R) is one of the main challenges in acute kidney damage. This study was designed to assess the anti-inflammatory and protective effects of P. crispum extract against I/R-induced renal disorders. <strong>Methods:</strong> Forty male rats were randomly divided into five groups (n=8) namely normal control (saline) and I/R control group, and three groups of I/R intraperitoneally pretreated with various doses of P. crispum (100, 150 and 200mg/kg). The I/R-induced renal inflammation was evaluated by determining leukocyte infiltration and mRNA expression level of intercellular adhesion molecule-1 and tumor necrotic factor-alpha. Antioxidant capacity of kidneys and thiobarbituric acid reactive species were measured in kidneys for the evaluation of oxidative stress. In addition, the diameters of renal glomeruli, kidney function indicators and serum nitrite oxide levels were respectively determined by morphometric analysis, autoanalyzer device and Griess technique. <strong>Results:</strong> The I/R increased all measured parameters except for the tissue ferric reducing/antioxidant power (FRAP) level, which was decreased compared to the normal control group. However, pretreatment with P. crispum extract in all doses significantly reduced blood urea nitrogen, kidney malondialdehyde, creatinine, glomerular diameter, leukocyte infiltration, levels of tumor necrotic factor-alpha, adhesion molecule-1 expression, and nitrite oxide as well as increased tissue FRAP compared to the I/R control group. <strong>Conclusion:</strong> It seems that P. crispum administration improves I/R-induced acute kidney injury.</div>
Petroselinum crispum, Injury, Kidney.
129
139
http://ppj.phypha.ir/browse.php?a_code=A-10-1165-1&slc_lang=en&sid=1
Shiva
Roshankhah
roshankhah@kums.ac.ir
3200319475328460029583
3200319475328460029583
No
Department of Anatomy, Medical School, Kermanshah University of Medical Sciences, Kermanshah, Iran
Cyrus
Jalili
cjalili@kums.ac.ir
3200319475328460029584
3200319475328460029584
No
Medical Biology Research Center, Department of Anatomy, Kermanshah University of Medical Sciences, Kermanshah, Iran
Mohammad Reza
Salahshoor
mr.salahshour@kums.ac.ir
3200319475328460029585
3200319475328460029585
Yes
Department of Anatomy, Medical School, Kermanshah University of Medical Sciences, Kermanshah, Iran