Physiology and Pharmacology
Physiol Pharmacol
Medical Sciences
http://ppj.phypha.ir
32
journal32
24765236
24765244
10.61186/phypha
(previous ISSN: 17350581)
en
jalali
1400
4
1
gregorian
2021
7
1
25
2
online
1
fulltext
en
The effect of vitamin D therapy on glycemic control and biochemical indices in type 2 diabetic patients: a randomized, clinical trial study
Endocrine Physiology/Pharmacology
Endocrine Physiology/Pharmacology
Experimental research article
Experimental research article
<div style="text-align: justify;"><strong>Introduction:</strong> The aim of the present study was to evaluate the effect of vitamin D on glycemic control and biochemical indices in type 2 diabetes. <strong>Methods:</strong> This randomized double blind placebo-controlled clinical trial was conducted on 80 patients with type 2 diabetes mellitus (T2DM) referred to Shahid Beheshti hospital. These patients were randomly classified into case and control groups. Case group consumed 50,000 IU of vitamin D once a week for 12 weeks and control group placebo. Biochemical and lipid parameters and vitamin D3 were measured in two groups. Glycosylated hemoglobin (HbA1c) was assessed by latex enhance immunoturbidimetric assay. <strong>Results: </strong>There was no significant difference between case and control groups in terms of age, sex, body mass index and used medications. The mean vitamin D level in case and control groups before intervention was 15.06 ±3.307 and 15.83± 2.509 ng/ml and after intervention was 49.77 ±15.73 and 14.91±3.13 ng/ml respectively. The mean fast blood sugar in case and control groups after intervention was 156.565±32.23 and 147.75±35.06 mg/dl, respectively. The mean HbA1c in case and control groups before intervention was 7.59± 0.39 % and 7.66± 0.38 % and after intervention was 7.26 ± 0.60 and 7.60 ± 0.38, respectively. Moreover, significant difference was seen between case (20.2± 5.74 IU/L) and control groups (23.35± 7.80 IU/L) in terms of alanine aminotransferase, after intervention. <strong>Conclusion: </strong>According to these findings, vitamin D supplementation possibly through decreasing HbA1C and hepatic alanine aminotransferase could improve diabetes complications.</div>
Glycemic control, Type 2 diabetes, Vitamin D.
125
133
http://ppj.phypha.ir/browse.php?a_code=A-10-1290-1&slc_lang=en&sid=1
Majid
Mozaffari
Mozaffari-m@kaums.ac.ir
3200319475328460029213
3200319475328460029213
Yes
Department of Internal Medicine, School of Medicine, Kashan University of Medical Sciences, Kashan, Iran
Hamed
Hajmoradi
3200319475328460029214
3200319475328460029214
No
Department of Internal Medicine, School of Medicine, Kashan University of Medical Sciences, Kashan, Iran
Alireza
Moravveji
3200319475328460029215
3200319475328460029215
No
Social Determinants of Health Research Center, Kashan University of Medical Sciences, Kashan, Iran
Fatemeh Sadat
Asgarian
3200319475328460029216
3200319475328460029216
No
Social Determinants of Health Research Center, Kashan University of Medical Sciences, Kashan, Iran
Parastoo
Noory
3200319475328460029217
3200319475328460029217
No
Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran