Physiology and Pharmacology
Physiol Pharmacol
Medical Sciences
http://ppj.phypha.ir
32
journal32
24765236
24765244
10.61186/phypha
(previous ISSN: 17350581)
en
jalali
1400
6
1
gregorian
2021
9
1
25
3
online
1
fulltext
en
The effect of swimming exercise on thyroid function, spatial memory and anxiety in normal and propylthiouracil-induced hypothyroidism in Wistar rats
Learning and Memory
Neurophysiology/Pharmacology
Experimental research article
Experimental research article
<div style="text-align: justify;"><strong>Introduction:</strong> Swimming exercises improve various nerve growth factors and angiogenesis that encouraged the researchers to investigate the effect of swimming exercises on thyroid function (cyclic adenosine monophosphate [cAMP] and dual oxidase 2 [DUOX2] in free T4 [FT4] secretion), spatial memory, behavior and anxiety on normal Wistar pups and those given with propylthiouracil (PTU). <strong>Methods:</strong> The subjects of this research were normal Wistar pups and those given 25 ppm PTU from the 1st week until the 12th week of age. Swimming activity was started in 4-weekold pups after acclimatization for 1 week. Swimming exercises were conducted with a load of 1–2% body weight and 30min duration per day, 5 times a week for 8 weeks. The levels of FT4 serum, cAMP and DUOX2 of the thyroid gland homogenate were measured using enzyme-linked immunosorbent assay. The rats’ ability to maintain spatial memory was measured using the Morris water maze and anxiety using the open field maze. <strong>Results: </strong>The FT4 levels significantly decreased after the administration of 25 ppm PTU for 3 weeks and it was much more decreased after 12 weeks administration. The administration of 25 ppm PTU for 12 weeks reduced the cAMP levels, increased DUOX2 and reduced the spatial memory skills and exploration behavior of rats. Swimming exercise increased and normalized these parameters. <strong>Conclusion:</strong> Swimming exercises for 8 weeks improve thyroid function, learning ability and spatial memory of normal and PTU-induced hypothyroid Wistar rats.</div>
Anxiety, cAMP, FT4, Propylthiouracil, Spatial memory.
231
241
http://ppj.phypha.ir/browse.php?a_code=A-10-1389-2&slc_lang=en&sid=1
Zulkhah
Noor
capa.journal116@klinikjurnal.com
3200319475328460029288
3200319475328460029288
Yes
Physiology Department, Faculty of Medicine and Health Sciences, Muhammadiyah University of Yogyakarta, Yogyakarta, Indonesia
Denny
Agustiningsih
3200319475328460029289
3200319475328460029289
No
Physiology Department, Faculty of Medicine, Public Health and Nursing, Gadjah Mada University, Yogyakarta, Indonesia
Marsetyawan HNE
Soesatyo
3200319475328460029290
3200319475328460029290
No
Histology Department, Faculty of Medicine, Public Health and Nursing, Gadjah Mada University, Yogyakarta, Indonesia
Sri Kadarsih
Soejono
3200319475328460029291
3200319475328460029291
No
Physiology Department, Faculty of Medicine and Health Sciences, Muhammadiyah University of Yogyakarta, Yogyakarta, Indonesia