Physiology and Pharmacology
Physiol Pharmacol
Medical Sciences
http://ppj.phypha.ir
32
journal32
24765236
24765244
10.61186/phypha
(previous ISSN: 17350581)
en
jalali
1401
6
1
gregorian
2022
9
1
26
3
online
1
fulltext
en
Changes in the electrical activity of prefrontal neurons following methamphetamine-induced conditioned place preference in the rat
Blood and Immune System
Blood and Immune System
Experimental research article
Experimental research article
<div style="text-align: justify;"><span class="fontstyle0"><strong>Introduction:</strong> </span><span class="fontstyle2">Methamphetamine (METH) addiction is an epidemic-growing problem globally. Studies confirmed a solid linkage between the prefrontal cortex (PFC) and drug seeking. The present study aimed to investigate PFC neural activity changes after injection of METH following METH-induced conditioned place preference (CPP) in the rats. </span><br />
<strong><span class="fontstyle0">Methods: </span></strong><span class="fontstyle2">After the development of CPP (0.5mg/kg METH for three days, SC), </span><span class="fontstyle3">in vivo </span><span class="fontstyle2">single-unit recordings were carried out the day after the post-test (post-conditioning day). On recording day, after stabilization and baseline recording (a 10-min period), the injection of METH (0.5mg/kg, SC) was performed and then, PFC neural activity was recorded for a 30-min period. </span><br />
<strong><span class="fontstyle0">Results: </span></strong><span class="fontstyle2">The results revealed that the injection of METH on the post-conditioning test significantly increases PFC neurons’ firing rate in animals that received METH during the CPP paradigm. </span><br />
<strong><span class="fontstyle0">Conclusion: </span></strong><span class="fontstyle2">It seems that maybe, PFC neurons appear to be implicated in the associated METH reward pathway and repeated exposure to METH affected the sensitivity of neurons in this area.</span></div>
Reward system, Prefrontal cortex, Methamphetamine, Neuronal activity, Conditioned place preference
288
298
http://ppj.phypha.ir/browse.php?a_code=A-10-1513-2&slc_lang=en&sid=1
Zahra
Taslimi
3200319475328460032679
3200319475328460032679
No
Neuroscience Research Center, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Abdolrahman
Sarihi
3200319475328460032680
3200319475328460032680
No
Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran
Sara
Karimi
3200319475328460032681
3200319475328460032681
No
Neuroscience Research Center, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Abbass
Haghparast
Haghparast@yahoo.com
3200319475328460032682
3200319475328460032682
Yes
Neuroscience Research Center, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran