Physiology and Pharmacology
Physiol Pharmacol
Medical Sciences
http://ppj.phypha.ir
32
journal32
24765236
24765244
10.61186/phypha
(previous ISSN: 17350581)
en
jalali
1402
6
1
gregorian
2023
9
1
27
3
online
1
fulltext
en
Cardioprotective effects of Ganoderma lucidum on isoproterenol–induced heart failure
Cardiovascular Physiology/Pharmacology
Cardiovascular Physiology/Pharmacology
Experimental research article
Experimental research article
<p>Introduction: Ganoderma lucidum (G. lucidum), a medicinal mushroom, exerts protective effects on cardiovascular diseases but, it’s effect in isoproterenol-induced heart failure has not been studied. Therefore, the aim of the present study was whether G. lucidum has protective effects in isoproterenol-induced heart failure.<br />
<strong>Methods:</strong> Thirty male Wistar rats were assigned into five groups (n=6) of control, heart failure (HF) and G. lucidum (50, 100 and 200mg/kg). For induction of HF in rats, isoproterenol (5mg/ kg) was injected subcutaneously for two weeks. In G. lucidum treated groups, G. lucidum was orally gavaged for three weeks and on day 8 isoproterenol was injected for two weeks. Then, Electrocardiogram pattern and cardiodynamic parameters, as well as myeloperoxidase activity, malondialdehyde level, cardiac remodeling and apoptosis were studied.<br />
<strong>Results:</strong> G. lucidum improved hemodynamic factors such as mean arterial blood pressure as well as electrocardiogram pattern. Pre-treatment with G. lucidum also decreased myeloperoxidase activity, malondialdehyde level and apoptosis in cardiac tissue. Histopathologic results showed a decrease in cardiac necrosis and fibrosis. However, it had no significant effect on cardiac hypertrophy.<br />
<strong>Conclusion:</strong> Our results show that pre-treatment with G. lucidum demonstrates protective effects against HF, and thereby suggest that G. lucidum can be considered as a possible clinical use for preventive and adjuvant treatment in heart failure.<span style="font-size:11pt"><span style="line-height:200%"><span style="text-autospace:none"><span style="font-family:Calibri,sans-serif"><span style="font-size:12.0pt"><span style="line-height:200%"><span style="font-family:"Times New Roman",serif"></span></span></span></span></span></span></span></p>
Ganoderma lucidum, Heart failure, Isoproterenol, Inflammation, Oxidative stress, Apoptosis
271
282
http://ppj.phypha.ir/browse.php?a_code=A-10-1741-2&slc_lang=en&sid=1
Monireh
Seiiedy
monirseiiedy72@gmail.com
3200319475328460033191
000000030602230X
No
Department of Pharmacology and Toxicology, School of Pharmacy, Urmia University of Medical Sciences, Urmia, Iran
Chiman
Salehi
salehichiman@gmail.com
3200319475328460033192
000000030602230X
No
Department of Pharmacology and Toxicology, School of Pharmacy, Urmia University of Medical Sciences, Urmia, Iran
Morteza
Ghasemnejad Berengi
morteza.ghasemnejad@yahoo.com
3200319475328460033193
0000000156729202
No
Department of Pharmacology and Toxicology, School of Pharmacy, Urmia University of Medical Sciences, Urmia, Iran
mojtaba
karimipour
mojtaba_karimipour@yahoo.com
3200319475328460033194
0000000228342892
No
Department of Anatomy, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran
Jafar
Rezaie
j.rezaie88@gmail.com
3200319475328460033195
0000000181753730
No
Solid Tumor Research Center, Cellular and Molecular Medicine Institute, Urmia University of Medical Sciences, Urmia, Iran
Shabnam
Babataheri
shabnambabataheri90@gmail.com
3200319475328460033196
000000030602230X
No
1Experimental and Applied Pharmaceutical Research Center, Urmia University of Medical Sciences, Urmia, Iran2Department of Pharmacology and Toxicology, School of Pharmacy, Urmia University of Medical Sciences, Urmia, Iran
Hamid
Soraya
hamid_soraya2000@yahoo.com
3200319475328460033197
000000030602230X
Yes
Experimental and Applied Pharmaceutical Research Center, Urmia University of Medical Sciences, Urmia, IranDepartment of Pharmacology and Toxicology, School of Pharmacy, Urmia University of Medical Sciences, Urmia, Iran