Physiology and Pharmacology
Physiol Pharmacol
Medical Sciences
http://ppj.phypha.ir
32
journal32
24765236
24765244
10.61186/phypha
(previous ISSN: 17350581)
en
jalali
1402
9
1
gregorian
2023
12
1
27
4
online
1
fulltext
en
Neuroprotective effect of Acorus calamus Linn. extract on a rat model of chronic constriction injury of median nerve-induced peripheral neuropathy
Neurophysiology/Pharmacology
Neurophysiology/Pharmacology
Experimental research article
Experimental research article
<p style="text-align: justify;"><strong>Introduction:</strong> Acorus calamus Linn. from the Acoraceae family exhibits several benefits in neurological disorders but has not been studied for chronic constriction injury (CCI) of median nerve induced neuropathic pain. Damage to median nerve leads to work-related musculoskeletal disorders (WMSDs). this study aimed to assess the effects of the ethanolic root extract of Acorus calamus (EAC) on CCI-induced neuropathic pain and WMSDs in rats.<br />
<strong>Methods:</strong> Animals were randomly divided into 7 groups of 8 animals each. Group 1. Normal control, 2. Sham control, 3. CCI, 4. CCI+ vehicle (CMC), 5. CCI+gabapentin (50 mg/kg), 6. CCI+EAC (20 mg/kg), 7. CCI+EAC (40 mg/kg). On day 0, rats were subjected to the surgical procedure of exposure and ligation of the median nerve-produced CCI at the forearm level. Pain-sensitive tests (i.e., hot plate test, Randall Selitto test), and functional analysis (i.e., walking track) were performed. Total protein, lipid peroxidation, and histopathological changes were also estimated.<br />
<strong>Results:</strong> CCI significantly increased thermal and mechanical hyperalgesia, raised median functional index (walking track analysis), and induced biochemical and histological disruptions. Oral administration of EAC (40 mg/kg) and gabapentin (50 mg/kg) notably lowered CCI-induced nociceptive pain threshold, improved median nerve functional index, and mitigated tissue histological alterations.<br />
<strong>Conclusion: </strong>EAC has been found to decrease CCI-induced neuropathic pain of the median nerve. Its mechanisms likely involve neuroprotective, antioxidant, and anti-inflammatory properties.</p>
Acorus calamus, Median nerve injury, Nerve functional index, Neuroprotection, Neuropathic pain, Walking track analysis
392
402
http://ppj.phypha.ir/browse.php?a_code=A-10-1747-1&slc_lang=en&sid=1
Shubhechha
Bansod
bansod.s1998@gmail.com
3200319475328460033640
0000000319377521
No
Bharati Vidyapeeth (Deemed to be University) Poona College of Pharmacy, Pune
Likhit
Akotkar
likhitakotkar254@gmail.com
3200319475328460033641
0000000342777806
No
Bharati Vidyapeeth (Deemed to be University) Poona College of Pharmacy, Pune, India
Subhash
Bodhankar
sbodh@yahoo.com
3200319475328460033642
0000000151682134
No
Bharati Vidyapeeth (Deemed to be University) Poona College of Pharmacy, Pune, India
Urmila
Aswar
aswarurmila@gmail.com
3200319475328460033643
0000000245667453
Yes
Associate Professor, Bharati Vidyapeeth (Deemed to be University) Poona College of Pharmacy, Pune, India