en
jalali
1396
12
1
gregorian
2018
3
1
22
1
online
1
fulltext
en
Executive functions are related to serum testosterone and basal metabolism rate fluctuation but not lymphocyte dopamine receptor expression in the young healthy participants
Introduction: Herein, we evaluated linkages between EFs performances and dopamine receptor (DR) mRNA and testosterone level in the young Iranian male people. Methods: All 140 participants were normalized using depression, anxiety and stress scale questionnaire. Remained 108 volunteers were tested against drug abuse and then volunteers were distinguished by Wisconsin Card Sorting Test (WSCT). According to WCST, participants were divided into two low and high EFs performance. Afterward, anthropometric factors, body mass index (BMI) and serum testosterone level were measured in low and high EFs groups. Blood samples were collected, and biochemical and anthropometric data were evaluated; serum testosterone and DR mRNA expression were assessed in participants. Results: Data showed there are no differences between two groups in Na+, K+, glucose, urea, creatinine, SGPT, SGOT and other biochemical serum agents (P>0.05) but BMI was increased in low EFs compared with high EFs (P=0.000). Interestingly, there is no difference in DR expression between two groups (P>0.05). Conclusion: Our data presented that fluctuation of EFs performances in healthy adult male cases might depend on BMI and serum testosterone; while dopamine receptors in the blood lymphocytes had no substantial role in the EFs. High serum testosterone reduced EFs in the young adults.
Executive function, Dopamine receptor, Testosterone, Young people, Blood lymphocytes, Body mass index
1
10
http://ppj.phypha.ir/browse.php?a_code=A-10-73-125&slc_lang=en&sid=1
2017/07/24
1396/5/2
2018/01/3
1396/10/13
Mitra-Sadat
Sadat-Shirazi
Department of Neuroscience, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
mitrasadat@gamil.com
00319475328460019125
00319475328460019125
No
Ghorbangol
Ashabi
Department of Physiology, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
as_habi@yahoo.com
00319475328460019126
00319475328460019126
No
Nima
Babhadiashar
Iranian National Center for Addiction Studies (INCAS), Tehran University of Medical Sciences, Tehran, Iran
bobhadiashar@yahoo.com
00319475328460019127
00319475328460019127
No
Mohammadreza
Bahrami Hessari
Faculty of Psychology & Education, Allameh Tabataba'i University, Tehran, Iran
Bahrami@gmail.com
00319475328460019128
00319475328460019128
No
Nasim
Vousooghi
Department of Neuroscience, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
dr.n.vosoughi@gmail.com
00319475328460019129
00319475328460019129
No
Mohammad-Reza
Zarrindast
Iranian National Center for Addiction Studies (INCAS), Tehran University of Medical Sciences, Tehran, Iran
zarinmr@ams.ac.ir
00319475328460019130
00319475328460019130
Yes
en
Preventive effect of natural dietary supplement -Flavin7- on the onset of spontaneous diabetes mellitus in bio-breeding diabetes prone rats
Introduction: The aim of the present study was to evaluate the preventive effects of Flavin7 in prediabetic bio-breeding diabetes prone (BB-DP) rats. Methods: Foutthy rats were divided into 2 equal groups: group C (untreated control group) and group F7 with Flavin7 (natural dietary supplement F7 with bioflavonoids, 0.2 mg/l) in drinking water from 21st day after birth to 171st day of their life, respectively. Blood glucose, superoxide dismutase, glutathione peroxidase, catalase, total antioxidant capacity, glutathione, body weight, food intake, water intake and urine output were determined. Results: The age of diabetes onset was significantly higher for group F7 compared to group C (P<0.05). The incidence of diabetes was lower in group F7 than in group C. Blood glucose at the diabetes onset was higher in group C than in F7 group (P<0.05). Decrease of antioxidant status parameters, at the treatment onset as well as immediately after its termination showed a drop in the F7 group firstly, but increased progressively later, until the end of the experiment. Conclusion: F7 delayed the development of diabetes in BB-DP rats and prevented its onset. The severity of diabetes mellitus was milder in rats treated with F7 than in control group.
Type 1 diabetes mellitus, BB-DP rats, Flavin7, Prevention of diabetes
11
18
http://ppj.phypha.ir/browse.php?a_code=A-10-1050-1&slc_lang=en&sid=1
2017/07/242017/11/15
1396/8/24
2018/01/32018/03/24
1397/1/4
František
Ništiar
Institute of Pathological Physiology, Faculty of Medicine, Šafárik University, Košice, Slovak Republic
frantisek.nistiar@upjs.sk
00319475328460019131
00319475328460019131
No
Agnesa
Lukačínová
Institute of Medical Physiology, Faculty of Medicine, Šafárik University, Košice, Slovak Republic
agnesa.lukacinova1@upjs.sk
00319475328460019132
00319475328460019132
No
Oliver
Rácz
Institute of Pathological Physiology, Faculty of Medicine, Šafárik University, Košice, Slovak Republic
oliver.racz@upjs.sk
00319475328460019133
00319475328460019133
No
Jaroslava
Nováková
Institute of Pathological Physiology, Faculty of Medicine, Šafárik University, Košice, Slovak Republic
jaroslava.novakova@upjs.sk
00319475328460019134
00319475328460019134
No
Eva
Lovásová
Institute of Pathological Physiology, Faculty of Medicine, Šafárik University, Košice, Slovak Republic
eva.lovasova@upjs.sk
00319475328460019135
00319475328460019135
No
Marek
Brenišin
Institute of Pathological Physiology, Faculty of Medicine, Šafárik University, Košice, Slovak Republic
marek.brenisin@upjs.sk
00319475328460019136
00319475328460019136
Yes
Simona
Rusnáková
Institute of Pathological Physiology, Faculty of Medicine, Šafárik University, Košice, Slovak Republic
simona.rusnakova@student.upjs.sk
00319475328460019137
00319475328460019137
No
en
Protective effects of rosuvastatin against hyperglycemia-induced oxidative damage in the pancreas of streptozotocin-induced diabetic rats
Introduction: According to the powerful antioxidant effects of rosuvastatin, the present study aimed to examine the protective effects of rosuvastatin against oxidative damage of diabetic pancreas by potentiation of the antioxidant capacity in streptozotocin-induced diabetic rats. Methods: Experiment was performed in four groups of male Wistar rats (n=6 in each group): normal, diabetic and two treatment groups (normal and diabetic rats treated with rosuvastatin). Rats were made diabetic by a single intravenous injection of streptozotocin (40 mg/kg) at the beginning of study. Treatment groups received orally rosuvastatin at dose of 10 mg/kg/day. After eight weeks, the pancreas tissues were removed under deep anesthesia. After tissue homogenization, the contents of glutathione and malondialdehyde (MDA) as well as superoxide dismutase (SOD) activity were assessed by biochemical methods. Results: Blood glucose of diabetic rats was above 350 mg/dl. The MDA content of the homogenized pancreas significantly increased in diabetic rats by 92%. Diabetes also decreased the content of glutathione (32%) as well as SOD activity (68%) of pancreas tissues. Treatment with rosuvastatin noticeably decreased the MDA levels of diabetic pancreas (90%). Moreover, rosuvastatin significantly increased the glutathione content (21%) and SOD activity (67%) of pancreas tissues in treated diabetic rats. Conclusion: Our findings reveal that rosuvastatin is able to attenuate the uncontrolled hyperglycemia-induced oxidative damage of pancreas through potentiation of the antioxidant defense system.
Diabetes mellitus, Rosuvastatin, Hyperglycemia, Oxidative damage, Antioxidant
19
27
http://ppj.phypha.ir/browse.php?a_code=A-10-589-7&slc_lang=en&sid=1
2017/07/242017/11/152017/09/26
1396/7/4
2018/01/32018/03/242018/03/13
1396/12/22
Samira
Yazdanimehr
Students' Research Committee, Baqiyatallah University of Medical Sciences, Tehran, Iran
smehr461@yahoo.com
00319475328460019138
00319475328460019138
No
Mohammad Taghi
Mohammadi
Exercise Physiology Research Center, Life Style Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran
Mohammadimohammadt@bmsu.ac.ir
00319475328460019139
00319475328460019139
Yes
en
The effect of saffron aqueous extract on oxidative stress parameters and important biochemical enzymes in the testis of streptozotocin-induced diabetic rats
Introduction: Sexual dysfunction and infertility are frequently associated with diabetes in men and experimental animals. Oxidative stress and alteration in testis are responsible for complication in diabetes. Saffron has antidiabetic and antioxidant properties that improves the functions of various organs. Therefore, the aim of the present study was to investigate the effects of administration of saffron aqueous extract in testis tissues of diabetic rats. Methods: The fasted rats were injected by a single intraperitoneal (ip) injection of a freshly prepared solution of streptozocin (STZ, 65mg/kg) in 0.1 M cold citrate buffer (pH=4.5). Three days after STZ administration, the animals with fasting blood glucose concentrations of over 250mg/dl were considered to be diabetic and were used in the experimental groups as follows: normal control (1), diabetic control (2), saffron control (3) and saffron treated (4). The treatment was started on the 7th day after STZ injection with ip injection of saffron (200mg/kg), five doses and weekly to groups (3 and 4). At the end of the experimental period, fasting blood glucose levels and the activity of ALT, AST, ALP, LDH, SOD, CAT, GPx and MDA content were determined in testis tissues. Results: Results showed saffron administration decreased elevated biochemical enzymes levels in testis of diabetic rats. Also, saffron significantly increased CAT and GPx activities in testis of diabetic rats. MDA levels had no significant changes in all experimental groups. Conclusion: The results demonstrated that saffron administration improved antioxidant enzymes function against oxidative stress.
Saffron aqueous extract, Diabetes mellitus, Testis, Biochemical and Antioxidant enzymes
28
37
http://ppj.phypha.ir/browse.php?a_code=A-10-1008-1&slc_lang=en&sid=1
2017/07/242017/11/152017/09/262017/04/28
1396/2/8
2018/01/32018/03/242018/03/132018/01/3
1396/10/13
Mahmoud
Hasanpour
Department of Basic Sciences, School of Veterinary Medicine, Shiraz University, Shiraz, Iran
hasanpoor@shirazu.ac.ir
00319475328460019140
00319475328460019140
No
Mahboobeh
Ashrafi
Department of Basic Sciences, School of Veterinary Medicine, Shiraz University, Shiraz, Iran
mashrafi@shirazu.ac.ir
00319475328460019141
00319475328460019141
No
Hoda
Erjaee
Department of Basic Sciences, School of Veterinary Medicine, Shiraz University, Shiraz, Iran
hoda.erjaee@gmail.com
00319475328460019142
00319475328460019142
No
Saeed
Nazifi
Department of Clinical Studies, School of Veterinary Medicine, Shiraz University, Shiraz, Iran
nazifi@shirazu.ac.ir
00319475328460019143
00319475328460019143
Yes
en
Carbon nanotubes provide longer lasting gastroprotective effects for anandamide in stress-induced gastric ulcer in rat
Introduction: Anandamide (AEA) has shown a wide spectrum of pharmacological activities including the effects against the peptic ulcer, meanwhile, the poor solubility or short half-life may negatively affect the effectiveness of this valuable cannabinoid. Based on the superior properties of carbon nanotubes (CNTs) for controlled drug delivery, we aimed to prepare AEA-CNTs complex and evaluate its therapeutic potential in an experimental model of gastric ulcer. Methods: Amino-functionalized multi-walled CNTs-AEA (MWCNTs-AEA) complex was prepared using COOH-MWCNTs and then characterized by Fourier transform infrared spectroscopy and transmission electron microscopy. Gastric ulcer was induced by water immersion and restrain stress (WRS) for 3.5 and 6 h in rats and the gastric lesion and oxidative stress were evaluated. Results: AEA at higher doses reduced the gastric ulcer area and malondialdehyde content and elevated glutathione level and superoxide dismutase and catalase activities after 3.5-h WRS but it was ineffective after 6-h WRS. MWCNTs-AEA complex showed therapeutic effects after both 3.5- and 6-h WRS. Conclusion: Aminated MWCNTs are suitable carriers for AEA as they provide longer lasting effects for this cannabinoid. The antioxidant mechanism may be involved in the gastroprotective effects of MWCNTs-AEA complex.
Carbon nanotubes, Anandamide, Gastric ulcer, Rat
38
47
http://ppj.phypha.ir/browse.php?a_code=A-10-858-6&slc_lang=en&sid=1
2017/07/242017/11/152017/09/262017/04/282017/02/5
1395/11/17
2018/01/32018/03/242018/03/132018/01/32017/10/29
1396/8/7
Parichehr
Hassanzadeh
Nanotechnology Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
p-hassanzadeh@razi.tums.ac.ir
00319475328460019144
00319475328460019144
Yes
Elham
Arbabi
Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Teheran, Iran
arbabiavalelham@gmail.com
00319475328460019145
00319475328460019145
No
Fatemeh
Atyabi
Nanotechnology Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
atyabifa@tums.ac.ir
00319475328460019146
00319475328460019146
No
Rassoul
Dinarvand
Nanotechnology Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
Dinarvand@tums.ac.ir
00319475328460019147
00319475328460019147
No
en
Gastroprotective effect of sodium hydrosulfide against indomethacin-induced gastric ulcer in diabetic rats
Introduction: The incidence rate of gastric erosions and ulcers in diabetic patients are higher due to failure of mucosal antioxidant defense and maintain enough blood flow. The present study evaluated the gastro-protective effect of sodium hydrosulfide (NaHS) against indomethacin-induced gastric lesions in diabetic rats. Methods: In order to test anti-ulcer activity of NaHS against indomethacin, four diabetic groups of rats including diabetic control and 3 NaHS-treated groups received a single dose of physiologic saline or NaHS at 320, 640 and 1280 μg/kg respectively, 30 min before ulcer induction by indomethacin. Five hours later, the animals were killed and their stomachs were removed for macroscopically and microscopically evaluations. In order to evaluate the antacid effect of NaHS, 4 groups of diabetic rats received physiologic saline or NaHS at 320, 640 and 1280 μg/kg and 30 min later anesthetized, underwent a midline laparotomy and then their pylorus ligated. Five hours later, the animals were killed, their stomachs were removed and pH of gastric effluents were measured. Results: Indomethacin induced gastric lesions in glandular part of the stomach. NaHS at 640 and 1280 μg/kg significantly decreased the indomethacin-induced gastric lesions in diabetic rats. The pH of gastric effluents and mucus content increased by NaHS at doses of 640 and 1280 μg/kg. Macroscopic and microscopic observations showed that mucosal erosions induced by indomethacin were significantly inhibited by NaHS. Conclusion: results suggest NaHS through decreasing the rate of gastric acid output and increasing the mucus production, protected the gastric mucosa against indomethacin-induced gastric lesions in diabetic rats.
Diabetes, Gastric acid secretion, sodium hydrosulfide, Rat
48
53
http://ppj.phypha.ir/browse.php?a_code=A-10-35-6&slc_lang=en&sid=1
2017/07/242017/11/152017/09/262017/04/282017/02/52017/08/23
1396/6/1
2018/01/32018/03/242018/03/132018/01/32017/10/292018/01/3
1396/10/13
Nasim
Nazariani
Biology Department, Payame Noor University, Tehran, Iran
nazariani64@yahoo.com
00319475328460019148
00319475328460019148
No
Seyyed Ali
Mard
Alimentary Research Center, Physiology Research Center (PRC), Department of Physiology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
alimard77@gmail.com; mard-sa@ajums.ac.ir
00319475328460019149
00319475328460019149
Yes
Sima
Nasri
Biology Department, Payame Noor University, Tehran, Iran
s_nasri2000@yahoo.com
00319475328460019150
00319475328460019150
No
Ali
Veisi
Behbahan Faculty of Medical Sciences, Behbahan, Iran
00319475328460019151
00319475328460019151
No
en
The effect of carvacrol on transcription levels of Bcl-2 family proteins in hypertrophied heart of rats
Introduction: Cardiomyocytes apoptosis contributes to the development of left ventricular hypertrophy. The Bcl-2 family members are important regulators of mitochondrial pathway of apoptosis. Monoterpenoid phenol –carvacrol– possesses strong antioxidant properties. The present study aimed to evaluate the effect of carvacrol on transcription level of pro-apoptotic (Bad and Bax) and anti-apoptotic (Bcl-2 and BCL-xL) members of Bcl-2 family in hypertrophied hearts. Methods: Male Wistar rats (170-200 g) were divided into the following groups: (I) intact animals served as the control (Ctl), (II) un-treated rats subjected to aortic banding to induce left ventricular hypertrophy (H group), (III, IV, V and VI): carvacrol (C)-pretreated rats (5, 10, 25 and 50 mg/kg/day) subjected to aortic banding (H+C5, H+C10, H+C25 and H+C50 groups, respectively). Blood pressure was recorded through the carotid artery cannulation. Fibrosis was assessed by Masson’s trichrome staining. Gene expression was evaluated by real time-PCR technique. Results: In the H+C10, H+C25 and H+C50 groups mean arterial pressure (P<0.05, P<0.001 and P<0.001, respectively) and heart weight to body weight ratio (P<0.05, P<0.01 and P<0.001, respectively) were decreased significantly in comparison with H group. In the H group the Bad mRNA level was increased significantly compared to Ctl (P<0.001); while in the H+C10, H+C25 and H+C50 groups Bad mRNA level was decreased significantly (P<0.0 5, P<0.001 and P<0.001 vs. H). In H+C25 and H+C50 groups Bcl-2 and Bcl-xL mRNA were also up-regulated when compared with Ctl. Conclusion: Taken together, our results suggest that carvacrol may protect the hypertrophied heart against apoptosis by affecting transcription of Bcl-2 family members.
Cardiac hypertrophy, Apoptosis, Carvacrol, Bcl-2, Bax, Bad, Bcl-xl
54
62
http://ppj.phypha.ir/browse.php?a_code=A-10-1023-1&slc_lang=en&sid=1
2017/07/242017/11/152017/09/262017/04/282017/02/52017/08/232017/07/4
1396/4/13
2018/01/32018/03/242018/03/132018/01/32017/10/292018/01/32018/03/2
1396/12/11
Sara
Sadeghzadeh
Department of Physiology, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
z.mohammadpour@stu.yazd.ac.ir
00319475328460019152
00319475328460019152
No
Seyed Hasan
Hejazian
Department of Physiology, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
s.hejazian@ssu.ac.ir
00319475328460019153
00319475328460019153
No
Mohabbat
Jamhiri
Department of Physiology, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
00319475328460019154
00319475328460019154
No
Zeynab
Hafizibarjin
Department of Physiology, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
hafizi.219@ssu.ac.ir
00319475328460019155
00319475328460019155
No
Salman
Sadeghzadeh
Young Researchers and Elite Club, Yazd Branch, Islamic Azad University, Yazd, Iran
salman.sdzd@iauashkezar.ac.ir
00319475328460019156
00319475328460019156
No
Fatemeh
Safari
Department of Physiology, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
safarif@ssu.ac.ir
00319475328460019157
00319475328460019157
No
en
Protective effects of omega-3, atorvastatin, vitamin E and vitamin C against doxorubicin-induced cardiotoxicity in rats: a comparison study
Introduction: The stress-oxidative is involved in doxorubicin (DOX)-induced cardiotoxicity. Due to the potential and previous reported for antioxidant properties of atorvastatin, omega-3, vitamin E and vitamin C, their efficacy to prevention of DOX-induced cardiotoxicity was investigated in this study. Methods: Fifty-six male rats were divided into 8 groups which received omega-3, atorvastatin, vitamin E, vitamin C, normal saline and dimethyl sulfoxide (DMSO) via gavage for 14 days then a single dose of DOX (20 mg/kg) was injected intraperitoneally except two last groups that received only normal saline or DMSO. The level of oxidative stress parameters like ferric reducing ability of plasma (FRAP) before and after DOX injection and malondialdehyde (MDA) of heart were estimated. Also the histopathologic assessments were done on heart sample at the end of experimental period. Results: The results showed that compared to other agents, omega-3 could emerge as the most protection against DOX. Its pretreatment led to one of the most FRAP changing percent meanwhile less MDA value and cardio pathologic indexes almost close to control groups compared to that of other agents (P<0.01). Conclusion: Omega-3 may have a promising protective effect against DOX-induced cardio toxicity.
Doxorubicin, Omega-3, Vitamin E, Vitamin C, Atorvastatin, Cardiotoxicity
63
72
http://ppj.phypha.ir/browse.php?a_code=A-10-963-4&slc_lang=en&sid=1
2017/07/242017/11/152017/09/262017/04/282017/02/52017/08/232017/07/42017/11/12
1396/8/21
2018/01/32018/03/242018/03/132018/01/32017/10/292018/01/32018/03/22018/03/5
1396/12/14
Abbas
Alimoradian
Molecular and Medicine Research Center, Department of Pharmacology, School of Medicine, Arak University of Medical
alimoradian@arakmu.ac.ir
00319475328460019158
00319475328460019158
Yes
Hadi
Ansarihadipour
Molecular and Medicine Research Center, Department of Biochemistry and Genetics, School of Medicine, Arak University
Ansari@arakmu.ac.iro.com
00319475328460019159
00319475328460019159
No
Saeed
Changizi-Ashtiyani
Department of Physiology, School of Medicine, Arak University of Medical Sciences, Arak, Iran
dr.ashtiyani@arakmu.ac.ir
00319475328460019160
00319475328460019160
No
Ali
Chehrei
Endocrinology and Metabolism Research Center, Arak University of Medical Sciences, Arak, Iran
alichehrei@yahoo.com
00319475328460019161
00319475328460019161
No
Reza
Talebi
Department of Anatomy, Arak University of Medical Sciences, Arak, Iran
rezatalebi29@gmail.com
00319475328460019162
00319475328460019162
No
Sadaf
Davudian
mmunopharmacology Lab, Humanitas Research Hospital, 20089 Rozzano, Milan, Italy
sadaf.davoudian@humanitaresearch.it
00319475328460019163
00319475328460019163
No
Soheila
Rostami
Student Research Committee, Arak University of Medical Sciences, Arak, Iran
sadaf_davudian@yahoo.com
00319475328460019164
00319475328460019164
No