Volume 29, Issue 2 (June 2025)
Physiol Pharmacol 2025, 29(2): 219-231 |
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Mousavi-Niri N, Naseroleslami M, Ghanimati E, Moheb-Alian M, Abdollah-pour F, Khakpai F. Stevia and especially Nano-Stevia induced anti diabetic, antidepressant, and analgesic effects in streptozotocin-induced diabetic rats. Physiol Pharmacol 2025; 29 (2) :219-231
URL: http://ppj.phypha.ir/article-1-2306-en.html
URL: http://ppj.phypha.ir/article-1-2306-en.html
Neda Mousavi-Niri 
, Maryam Naseroleslami , Elham Ghanimati , Marzieh Moheb-Alian , Faezeh Abdollah-pour , Fatemeh Khakpai
, Maryam Naseroleslami , Elham Ghanimati , Marzieh Moheb-Alian , Faezeh Abdollah-pour , Fatemeh Khakpai
Abstract: (1342 Views)
Introduction: Diabetes mellitus is a metabolic disease. This disease is almost associated with depression and impaired pain sensation. Stevia rebaudiana Bertoni (stevia) has a sweet taste and a useful effect in blood glucose control. This study was designed to evaluate the effect of Stevia and Nano-stevia on psychological problems (e.g. depression and pain) induced by diabetes.
Methods: By a single intraperitoneal administration of streptozotocin, diabetes mellitus was induced in male Wistar rats. Stevia (20 mg/dl per day for 30 days) and Nano-stevia (20 mg/dl per day for 30 days) were administrated intra-gastrically in diabetic rats. Using the forced swim test (FST) and formalin test, depression and pain behaviors were measured, respectively.
Results: The results exhibited that male diabetic rats showed hyperglycemia, depressant-related behavior, and hyperalgesic response. On the other hand, intragastric usage of Stevia (20 mg/dl per day for 30 days) and Nano-stevia (20 mg/dl per day for 30 days) modified the hyperglycemia, depressant-related response, and hyperalgesic effect in diabetic rats. Nano-stevia indicated the maximum significant response rather than Stevia.
Conclusion: The results of this study indicate that Stevia and particularly Nano-stevia could be beneficial in managing diabetes and its associated behavioral complications.
Methods: By a single intraperitoneal administration of streptozotocin, diabetes mellitus was induced in male Wistar rats. Stevia (20 mg/dl per day for 30 days) and Nano-stevia (20 mg/dl per day for 30 days) were administrated intra-gastrically in diabetic rats. Using the forced swim test (FST) and formalin test, depression and pain behaviors were measured, respectively.
Results: The results exhibited that male diabetic rats showed hyperglycemia, depressant-related behavior, and hyperalgesic response. On the other hand, intragastric usage of Stevia (20 mg/dl per day for 30 days) and Nano-stevia (20 mg/dl per day for 30 days) modified the hyperglycemia, depressant-related response, and hyperalgesic effect in diabetic rats. Nano-stevia indicated the maximum significant response rather than Stevia.
Conclusion: The results of this study indicate that Stevia and particularly Nano-stevia could be beneficial in managing diabetes and its associated behavioral complications.
Type of Manuscript: Experimental research article |
Subject:
Neurophysiology/Pharmacology
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