Volume 16, Issue 4 (Winter 2013)
Physiol Pharmacol 2013, 16(4): 423-434 |
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Solati M, Farshidfar G, Vakil M K, Saberi P, Kamalinejad M, Soltani N. Effect of administration of Teucrium polium on blood glucose and lipid levels in. Physiol Pharmacol 2013; 16 (4) :423-434
URL: http://ppj.phypha.ir/article-1-833-en.html
URL: http://ppj.phypha.ir/article-1-833-en.html
Mehrdad Solati 
, Golamreza Farshidfar , Mohammad Kazam Vakil , Paknoush Saberi , Mohammad Kamalinejad , Nepton Soltani
, Golamreza Farshidfar , Mohammad Kazam Vakil , Paknoush Saberi , Mohammad Kamalinejad , Nepton Soltani
Abstract: (13852 Views)
Introduction: Recently, the search for appropriate hypoglycemic agents has been focused on plants. Teucrium
polium is traditionally used in Iran to manage, control and treat diabetes. We designed this study to elucidate the effect
of the administration of oral doses of aqueous and ethanol extract from Teucrium polium on plasma glucose, lipid
profiles and liver enzymes in diabetic and non diabetic rats.
Methods: In this study, we used 50 rats, which were divided into 5 groups (n=10): two groups served as nondiabetic
controls (NDC), while the other groups had diabetes induced with a single injection of streptozotocin (STZ).
Teucrium polium-treated chronic diabetic (TE-CD) and Teucrium polium-treated controls (TE-C) received 1g/l of
Teucrium polium added to their drinking water for 8 weeks.
Results: Administration of Teucrium polium caused Ca/Mg ratio, plasma glucose, glucose tolerance test (IPGTT),
high density lipoprotein (HDL), triglyceride, very low density lipoprotein (VLDL) concentrations to return to normal
levels, but total cholesterol and low density lipoprotein (LDL) and liver enzyme were increased.
Conclusion: Our results support the hypothesis that Teucrium polium could play a role in the management of
diabetes, but it has toxic effects on the liver in STZ-induced diabetic rats. It seems that Teucrium polium cannot be used
for prevention of type one diabetes.
Type of Manuscript: Experimental research article |
Subject:
Endocrine Physiology/Pharmacology
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