Volume 21, Issue 2 (June 2017)                   Physiol Pharmacol 2017, 21(2): 88-101 | Back to browse issues page

XML Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Nikseresht S, Khodagholi F, Ahmadiani A. Actors of necroptosis scenario in cell's scene. Physiol Pharmacol 2017; 21 (2) :88-101
URL: http://ppj.phypha.ir/article-1-1246-en.html
Abstract:   (3206 Views)

Necroptosis, as a novel concept, has been recently introduced in scientific literature. Much of our knowledge about necroptosis comes from ligation of tumor necrosis factor-α to its receptor, TNF receptor 1. Receptor-interacting protein kinase 1, receptor-interacting protein kinase 3 and its substrate, the pseudokinase mixed lineage kinase domain-like protein, have been comprehensively studied as influential components of this process. Emerging pioneering evidence suggests that many molecules, organelles and mechanisms are involved in necroptosis pathway. The aim of this review is presentation of molecular mechanisms of necroptosis in three phases including initiation, regulation and execution of necroptosis. Moreover, this review will summarize unprecedented insights into the contribution of various organelles and cell compartments such as mitochondria, endoplasmic reticulum, nucleus, lysosomes and Golgi apparatus in necroptosis pathway.

Full-Text [PDF 787 kb]   (883 Downloads)    
Type of Manuscript: Review | Subject: Cell, Stem Cell and Cancer

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.