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Abstract:   (45 Views)
this study aimed to investigate the effects of gallic acid and cyclosporine A(CsA) together on Electrocardiogram (ECG) parameters in myocardium following ischemia - reperfusion (I/R) in isolated hearts.
Method: in this original research, 50Wistar rats weighing 250-300- g were randomly divided into the 5 following groups: control, sham, gallic acid  (7.5, 15 and 30 mg / kg), +(CsA ,0.2 µM). On the eleventh day, the hearts were removed and perfused with Krebs solution and ischemia was induced for 30 minutes. Then, cyclosporine was administered for 10 minutes at the 10 minutes before reperfusion and 10 minutes the beginning of reperfusion. By placing the electrode, the parameters of RR, PR, QT, TpeakTend, JT and QTcB interval, ST elevation, R, P, Q, S, T amplitude were recorded before ischemia, and during reperfusion. The results were analyzed by ANOVA repeated measurement and post hoc LSD test at a significant level of p≤0.05.
Result:  this study showed that RR, JT, interval, p duration, ST elevation and PVC numbers of control were increased during ischemia compared with sham and decreased using gallic acid (7.5, 15 and 30 mg/kg) in combination with CsA, (P<0.05). In addition, P, R, S, T amplitude during the ischemia were decreased in control compared with sham and increased with gallic acid (15 mg/kg) in combination with CsA (P<0.05).
Conclusion: In conclusion, the optimal combination of both drugs G15 and 30 mg/Kg+ CsA decreased arrhythmia occurrence while increased electrical velocity of conduction and wave amplitudes in isolated myocardium after ischemia reperfusion injury.
     
Types of Manuscript: Original Research | Subject: Cardivascular system