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Noor Z, Agustiningsih D, Soesatyo M H, Soejono S K. The Effect of Swimming Exercise on Thyroid Function, Spatial Memory, and Anxiety in Normal and Propylthiouracil (PTU)-Induced Hypothyroidism in Wistar Rats. Physiol Pharmacol. 2021;
URL: http://ppj.phypha.ir/article-1-1638-en.html
Abstract:   (111 Views)
Introduction: That swimming exercises improve various nerve growth factors and angiogenesis encourage the researcher to investigate the effect of swimming exercises on thyroid function (cyclic adenosine monophosphate [cAMP] and dual oxidase 2 [DUOX2] in FT4 secretion), spatial memory, behavior, and anxiety on normal Wistar pups and those given propylthiouracil (PTU).
Method: The subjects of this research were normal Wistar pups and those given 25 ppm PTU from the 1st week until the 12th week of age. Swimming activity was started in 4-week-old pups after acclimatization for 1 week. Swimming exercises were conducted with a load of 1%–2% body weight and 30-min duration per day (frequency, 5 times a week for 8 weeks). The levels of FT4 serum, cAMP, and DUOX2 of the thyroid gland homogenate were measured using enzyme-linked immunosorbent assay. The rats’ ability to maintain spatial memory was measured using the Morris water maze and anxiety using the open field maze.
Results: The FT4 levels (p < 0.05) significantly decreased after the administration of 25 ppm PTU to pups for 3 weeks, and it was much more decreased after the administration for 12 weeks (p < 0.05). The administration of 25 ppm PTU for 12 weeks reduced the cAMP levels, increased DUOX2, and reduced the spatial memory skills and exploration behavior of rats (p < 0.05). Swimming exercise increased and normalized these parameters (p < 0.05).
Conclusions: Swimming exercises for 8 weeks help improve thyroid function, learning ability, and spatial memory of normal and PTU-induced hypothyroid Wistar rats.
     
Types of Manuscript: Original Research | Subject: Learning and memory

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