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Abstract:   (243 Views)
Introduction: Phenylhydrazine (PHZ)-induced anaemia is associated with oxidative damage to erythrocytes and impaired renal function. Fresh palm oil (FPO) is a rich source of antioxidants and preserves renal function. This study investigated the possible reno-protective effects of FPO in PHZ-induced anaemic Wistar rats.
Methods: Eighteen male Wistar rats (165 – 180 g) aged 8 – 9 weeks were randomly assigned into normal control (NC) (0.2 mL normal saline i.p), anaemic control (AC) (60 mg/kg of PHZ i.p) and anaemic treated (A + FPO) (60 mg/kg of PHZ + 15 % FPO diet) groups. PHZ was administered twice consecutively at 48 h interval while FPO diet was given throughout the study period (14 days). 
Results: Erythrocyte count, haemoglobin concentration and haematocrit were increased (p < 0.05) in A + FPO compared with AC. FPO improved imbalances in the levels of glucose and electrolytes (Na+, Cl-, K+, HCO3-) in serum and urine of the anaemic rats. Urea and creatinine concentrations were decreased (p < 0.05) in serum and increased (p < 0.05) in urine in the A + FPO relative to AC. Proteinuria was decreased (p < 0.05) in A + FPO compared with AC. The levels of malondialdehyde, pro-inflammatory cytokines and caspase-3 were downregulated (p < 0.05) in A + FPO compared with AC while interleukin-10 concentration, enzymatic antioxidants activities, and total antioxidant capacity were upregulated (p < 0.05) in A + FPO compared with AC. 
Conclusion: FPO demonstrated anti-anaemic effect and improved the impaired renal function associated with PHZ-induced anaemia.
Types of Manuscript: Original Research | Subject: Kidney

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