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Abstract:   (332 Views)
Object: Carbon monoxide (CO) intoxication is one of the most important poisoning related to high morbidity and mortality rate. The main treatment of CO poisoning is oxygen therapy using normobaric (NBO) or hyperbaric oxygen (HBO). However more pharmaceutical agents are needed to improve CO poisoning treatment especially in severe cases. Recently, erythropoietin (EPO) has been examined in several studies, showing significant reduction in cardiac and neural sequels of CO poisoning.
Method: In this article, the effect of EPO on cardio and neurotoxicity of CO poisoning were reviewed. For this purpose EPO effect on CO poisoning searched in papers published until 2020 using Pubmed, Scopuse and google scholar.
Limitation: Only English papers in three main data base have been reviewed.
Result and conclusion: The review of several animal and clinical studies have been shown EPO administration after CO poisoning could improve neurological function and reduce CO-neurotoxicity significantly. Although there are good evidences in EPO effects on CO induced-neurological sequelae, further clinical studies are needed to establish its benefit on CO intoxication.
     
Types of Manuscript: Mini-review | Subject: Pharmacokinetics/Dynamics

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