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Abstract:   (42 Views)
Introduction:­Stress adversely influences brain functions, whereas escitalopram exhibits positive effects on cognitive processes. This study investigated the protective effect of different dose of escitalopram on cognitive function in rats under normal and chronic stress condition.
Methods:­Forty-nine rats were randomly allocated into seven groups: Control, Stress, Sham, Escitalopram (doses of 10 and 20 mg/kg) and Stress-Escitalopram (both doses of 10 and 20 mg/kg). Initial latency, latency after 1-day, dark stay (DS) time and the number of entrance to the dark compartment were evaluated by passive avoidance test.
Results:­There were significant differences on latency in St and Esc10 groups compared to control group. The latency showed significant enhancements in St-Esc10 and St-Esc20 groups in comparison with St group. Also, the latency showed significant decreases in the Esc20 group in comparison with the Esc10 group. Moreover, DS time was significantly higher in St group than control group. The DS time significantly decreased in Esc10 group compared to control group, as well as in St-Esc10, St-Esc20 compared to St group. The Ds significantly was higher in Esc20 than Esc10 group. Furthermore, the number of entrance to dark compartment was significantly lower in the St, Esc10 and St-Esc10 groups compared to that in control group.
Conclusion:­It is concluded that escitalopram had various effects on brain functions under normal and chronic stress conditions. It seems that escitalopram (10 mg/kg) had the best effect on improvement of brain function in normal condition. Whereas, both doses of escitalopram showed the same protective effect on memory under stress condition.
     
Types of Manuscript: Original Research | Subject: Learning and memory