Volume 26, Issue 2 (June 2022)                   Physiol Pharmacol 2022, 26(2): 119-126 | Back to browse issues page

XML Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Khazdair M R, Amirabadizadeh A. Therapeutic effects of Nigella sativa on asthma: a systematic review of clinical trial. Physiol Pharmacol 2022; 26 (2) :119-126
URL: http://ppj.phypha.ir/article-1-1724-en.html
Therapeutic effects of Nigella sativa on asthma: a systematic review of clinical trial
Mohammad Reza Khazdair , Alireza Amirabadizadeh
Abstract:   (2326 Views)
Introduction: Nigella sativa (N. sativa)in the family of Ranunculaceae, has been traditionally used as food additive and spice. N. sativa showed protective effects on respiratory system including trachea responsiveness and lung inflammation in various animals’ models studies. The possible therapeutic effects of N. sativa on asthma were investigated in this systematic review study. Methods: The published studies were searched in the different databases including; PubMed, Web of Science (ISI), Scopus and Cochrane, until September 2020, by: (asthma) AND (“Nigella sativa”) OR (“Nigella sativa oil”) OR (Black seed). All unrelated articles such as duplicates, animal and review studies as well as clinical studies without control group were excluded from obtained studied. Then 9 articles were considered for further evaluation. Results: After analyzing 9 articles including 434 participants, these following results were achieved: N. sativa improved the asthma control test and pulmonary function tests values, while reduced respiratory symptoms including, cough and wheeze. Furthermore, N. sativa, reduced eosinophils count and serum levels of pro-inflammatory mediators such as interleukin-4 and immunoglobulin E, while increased production of anti-inflammatory mediator such as interferon-γ in the serum. Conclusion: The results of this systematic review article revealed that supplementation of N. sativa might be effective in the control or treatment of asthma.
 
Keywords: Nigella sativa, Asthma, Airway inflammation, Pulmonary function test, Respiratory symptoms
Full-Text [PDF 3048 kb]   (727 Downloads)    
Type of Manuscript: Review | Subject: Blood and Immune System
References
1. Ahmad J, Khan RA, Malik MA. A study of Nigella sativa oil in the management of wheeze associated lower respiratory tract illness in children. Afr J Pharm Pharmacol 2010; 4: 436-9.
2. Al-Jawad FH, Al-Razzuqi RA, Hashim HM, Ismael AH. Broncho-relaxant activity of Nigella sativa versus anthemisnobilis in chronic bronchial asthma; a comparative study of efficacy. IOSR J Pharmac 2012; 2: 81-3. [DOI:10.9790/3013-24208183]
3. Al-Moamary MS, Alhaider SA, Al-Hajjaj MS, Al-Ghobain MO, Idrees MM, Zeitouni MO, et al. The Saudi initiative for asthma-2012 update: guidelines for the diagnosis and management of asthma in adults and children. Ann Thorac Med 2012; 7: 175. [DOI:10.4103/1817-1737.102166]
4. Al Ameen N, Altubaigy F, Jahangir T, Mahday IA, Mohammed EA, Musa O. Effect of Nigella sativa and bee honey on pulmonary, hepatic and renal function in Sudanese in Khartoum state. J Med Plant Res 2011; 5: 6857-63. [DOI:10.5897/JMPR11.1357]
5. Alavinezhad A, Khazdair MR, Boskabady MH. Possible therapeutic effect of carvacrol on asthmatic patients: A randomized, double blind, placebo‐controlled, Phase II clinical trial. Phytotherapy Research 2018; 32: 151-9. [DOI:10.1002/ptr.5967]
6. Barlianto W, Rachmawati M, Irawan M, Wulandari D. Effects of Nigella sativa oil on Th1/Th2, cytokine balance, and improvement of asthma control in children. Paediatr Indones 2017; 57: 223-8. [DOI:10.14238/pi57.5.2017.223-8]
7. Barlianto W, Wulandari D, Chusniyah M, Chandra Kusuma HMS, Prawiro SR. Improvement of th17/treg balance and asthma control test score by nigella sativa supplementation in asthmatic children: A new approach to managing asthma. Turk J Immunol 2018; 6: 1-7. [DOI:10.25002/tji.2018.686]
8. Barnes PJ. Drugs for asthma. British journal of pharmacology 2006; 147: S297-S303. [DOI:10.1038/sj.bjp.0706437]
9. Bateman E, Hurd S, Barnes P, Bousquet J, Drazen J, FitzGerald M, et al. Global strategy for asthma management and prevention: GINA executive summary. Eur Respir J 2008; 31: 143- 78. [DOI:10.1183/09031936.00138707]
10. Bordoni L, Fedeli D, Nasuti C, Maggi F, Papa F, Wabitsch M, et al. Antioxidant and antiinflammatory properties of Nigella sativa oil in human pre-adipocytes. Antioxidants 2019; 8: 51. [DOI:10.3390/antiox8020051]
11. Boskabady M, Kiani S, Jandaghi P. Stimulatory effect of Nigella sativa on β2-adrenoceptors of guinea pig tracheal chains. Med j Islam Repub Iran 2004; 18: 153-158.
12. Boskabady M, Mohsenpoor N, Takaloo L. Antiasthmatic effect of Nigella sativa in airways of asthmatic patients. Phytomedicine 2010; 17: 707-13. [DOI:10.1016/j.phymed.2010.01.002]
13. Boskabady MH, Farhadi J. The possible prophylactic effect of Nigella sativa seed aqueous extract on respiratory symptoms and pulmonary function tests on chemical war victims: a randomized, double-blind, placebo-controlled trial. J Altern Complement Med 2008; 14: 1137-44. [DOI:10.1089/acm.2008.0049]
14. Boskabady MH, Javan H, Sajady M, Rakhshandeh H. The possible prophylactic effect of Nigella sativa seed extract in asthmatic patients. Fundam Clin Pharmacol 2007; 21: 559-66. [DOI:10.1111/j.1472-8206.2007.00509.x]
15. Bousquet J, Jeffery PK, Busse WW, Johnson M, Vignola AM. Asthma: from bronchoconstriction to airways inflammation and remodeling. Am J Respir Crit Care Med 2000; 161: 1720-45. [DOI:10.1164/ajrccm.161.5.9903102]
16. Chehl N, Chipitsyna G, Gong Q, Yeo CJ, Arafat HA. Anti-inflammatory effects of the Nigella sativa seed extract, thymoquinone, in pancreatic cancer cells. HPB 2009; 11: 373-81. [DOI:10.1111/j.1477-2574.2009.00059.x]
17. Cohn L, Elias JA, Chupp GL. Asthma: mechanisms of disease persistence and progression. Annu Rev Immunol 2004; 22: 789-815. [DOI:10.1146/annurev.immunol.22.012703.104716]
18. Durmuskahya C, Ozturk M. Ethnobotanical survey of medicinal plants used for the treatment of diabetes in Manisa, Turkey. Sains Malaysiana 2013; 42: 1431-8.
19. Düzelme D. Improvement of Th17/Treg balance and Asthma Control Test score by Nigella sativa supplementation in asthmatic children: a new approach to managing asthma. Turk J Immunol 2018; 6: 1-7. [DOI:10.25002/tji.2018.686]
20. Emeka LB, Emeka PM, Khan TM. Antimicrobial activity of Nigella sativa L. seed oil against multi-drug resistant Staphylococcus aureus isolated from diabetic wounds. Pak J Pharm Sci 2015; 28: 1985-90.
21. Gholamnezhad Z, Boskabady MH, Khazdair MR, Hosseini M, Abbasnejad M. Effect of fluticasone and salmeterol on tracheal responsiveness to ovalbumin and lung inflammation, administrated during and after sensitization. Sci World J 2014; 2014. [DOI:10.1155/2014/865292]
22. Gilani A, Aziz N, Khurram I, Chaudhary K, Iqbal A. Bronchodilator, spasmolytic and calcium antagonist activities of Nigella sativa seeds (Kalonji): a traditional herbal product with multiple medicinal uses. J Pak Med Assoc 2001; 51: 115.
23. Greenberger P A. Therapy in the management of the rhinitis/asthma complex. Journal 2003; 24: 403-7.
24. Hajhashemi V, Ghannadi A, Jafarabadi H. Black cumin seed essential oil, as a potent analgesic and antiinflammatory drug. Phytother Res 2004; 18: 195-9. [DOI:10.1002/ptr.1390]
25. Janssen L J, Killian K. Airway smooth muscle as a target of asthma therapy: history and new directions. Respir Res 2006; 7: 123. [DOI:10.1186/1465-9921-7-123]
26. Kalus U, Pruss A, Bystron J, Jurecka M, Smekalova A, Lichius JJ, et al. Effect of Nigella sativa (black seed) on subjective feeling in patients with allergic diseases. Phytother Res 2003; 17: 1209-14. [DOI:10.1002/ptr.1356]
27. Khazdair M, Boskabady M, Tabatabaee A, Hosseini M, Abbasnejad M. Effect of inhaled fluticasone and salmeterol on tracheal responsiveness and lung inflammation: influence of administration time and allergen-free period. Indian J Med Res 2013; 67: 78. [DOI:10.4103/0019-5359.121121]
28. Khazdair MR. The Protective Effects of Nigella sativa and Its Constituents on Induced Neurotoxicity. J Toxicol 2015; 2015. [DOI:10.1155/2015/841823]
29. Khazdair MR, Anaeigoudari A, Hashemzehi M, Mohebbati R. Neuroprotective potency of some spice herbs, a literature review. J Tradit Complement Med 2019a; 9: 98-105. [DOI:10.1016/j.jtcme.2018.01.002]
30. Khazdair MR, Anaeigoudari A, Kianmehr M. Anti-Asthmatic Effects of Portulaca Oleracea and its Constituents, a Review. J Pharmacopunct 2019b; 22: 122.
31. Koolen B, Pijnenburg M, Brackel H, Landstra A, Van den Berg N, Merkus P, et al. Comparing global initiative for asthma (GINA) criteria with the childhood asthma control test (C-ACT) and asthma control test (ACT). Eur Respir J 2011; 38: 561-6. [DOI:10.1183/09031936.00173710]
32. Koshak A, Wei L, Koshak E, Wali S, Alamoudi O, Demerdash A, et al. Nigella sativa supplementation improves asthma control and biomarkers: A randomized, double‐blind, placebo‐controlled trial. Phytother Res 2017; 31: 403-409. [DOI:10.1002/ptr.5761]
33. Mahmood MS, Gilani A, Khwaja A, Rashid A, Ashfaq M. The in vitro effect of aqueous extract of Nigella sativa seeds on nitric oxide production. Phytother Res 2003; 17: 921-4. [DOI:10.1002/ptr.1251]
34. Majdalawieh A F, Hmaidan R, Carr R I. Nigella sativa modulates splenocyte proliferation, Th1/Th2 cytokine profile, macrophage function and NK anti-tumor activity. J Ethnopharmacol 2010; 131: 268-75. [DOI:10.1016/j.jep.2010.06.030]
35. Mohebbati R, Shafei MN, Beheshti F, Soukhtanloo M, Roshan NM, Anaeigoudari A, et al. Mixed hydroalcoholic extracts of Nigella sativa and Curcuma longa improves adriamycininduced renal injury in rat. Saudi J Kidney Dis Transpl 2017; 28: 1270. [DOI:10.4103/1319-2442.220880]
36. Mohebbatia R, Khazdair MR, Karimia S, Abbasnezhadd A. HepatoprotectiveEffects of Combination Hydroalcoholic Extracts of Nigella Sativa and Curcuma Longa on AdriamycinInduced Oxidative Stress in Rat. J Rep Pharm Sci 2017a; 6: 93-102.
37. Mohebbatia R, Khazdairb M R, Hedayatia M. Neuroprotective Effects of medicinal plants and their constituents on different induced neurotoxicity methods: A review. J Rep Pharm Sci 2017b; 6: 34-50.
38. Mokhtari-Zaer A, Norouzi F, Askari VR, Khazdair MR, Roshan NM, Boskabady M, et al. The protective effect of Nigella sativa extract on lung inflammation and oxidative stress induced by lipopolysaccharide in rats. J Ethnopharmacol 2020; 253: 112653. [DOI:10.1016/j.jep.2020.112653]
39. Mortazavi Moghaddam SG, Kianmehr M, Khazdair MR. The possible therapeutic effects of some medicinal plants for chronic cough in children. Evid Based Complement Alternat Med 2020; 2020. [DOI:10.1155/2020/2149328]
40. Nasir A, Siddiqui M, Mohsin M. Therapeutic uses of Shoneez (Nigella sativa Linn.) mentioned in unani system of medicine-A Review. Int J Pharm Phytopharmaco Res 2014; 4: 47-9.
41. Nasuti C, Fedeli D, Bordoni L, Piangerelli M, Servili M, Selvaggini R, et al. AntiInflammatory, anti-arthritic and anti-nociceptive activities of Nigella sativa oil in a rat model of arthritis. Antioxidants 2019; 8: 342. [DOI:10.3390/antiox8090342]
42. Packard K A, Khan MM. Effects of histamine on Th1/Th2 cytokine balance. Int Immunopharmacol 2003; 3: 909-20. [DOI:10.1016/S1567-5769(02)00235-7]
43. Salem AM, Bamosa AO, Qutub HO, Gupta RK, Badar A, Elnour A, et al. Effect of Nigella sativa supplementation on lung function and inflammatory mediators in partly controlled asthma: a randomized controlled trial. Ann Saudi Med 2017; 37: 64-71. [DOI:10.5144/0256-4947.2017.64]
44. Shahzad M, Yang X, Asim MR, Sun Q, Han Y, Zhang F, et al. Black seed oil ameliorates allergic airway inflammation by inhibiting T-cell proliferation in rats. Pulm Pharmacol Ther 2009; 22: 37-43. [DOI:10.1016/j.pupt.2008.11.006]
45. Slader C A, Reddel HK, Jenkins CR, Armour CL, Bosnic-Anticevich SZ. Complementary and alternative medicine use in asthma: who is using what? Respirology 2006; 11: 373-87. [DOI:10.1111/j.1440-1843.2006.00861.x]
46. Tembhurne S, Feroz S, More B, Sakarkar D. A review on therapeutic potential of Nigella sativa (kalonji) seeds. J Med Plant Res 2014; 8: 167-77. [DOI:10.5897/JMPR10.737]
47. Wu D, Meydani M, Leka LS, Nightingale Z, Handelman GJ, Blumberg JB, et al. Effect of dietary supplementation with black currant seed oil on the immune response of healthy elderly subjects. The Am J Clin Nutr 1999; 70: 536-43. [DOI:10.1093/ajcn/70.4.536]
Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.