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Abstract:   (177 Views)
Introduction: The nasal airway a common route for normal breathing and difficulty in nasal breathing due to nasal blockage is associated with abnormal respiratory pattern during sleep. The aim of this study was to investigate whether alteration in nasal airflow can change respiration pattern variability.
Methods: Healthy male Wister rats were randomly divided into 4 groups, including control, saline, nasal obstruction and nasal anesthesia groups. The animals underwent bilateral nasal obstruction using cauterization. Respiration of conscious animals recorded using whole-body plethysmography.
Results: Respiratory signal analysis showed a greater variability of respiratory rhythm in both nasal obstruction and nasal anesthetized animals with higher variability in expiration time, inter-breath interval (IBI), greater expiration to inspiration time ratio, mean IBI and decrease in respiratory rate. Our results also showed a higher irregularity in respiratory pattern, which characterized with higher respiration frequency and periodic respiratory pattern in nasal obstruction animals.
Conclusion: Therefor this result proposed that sensory information raised form the flow receptor lying in nasal airway may be, regulating the neuronal firing activity in respiratory center, which creates normal ventilatory pattern variability.
Key word: nasal obstruction, respiratory pattern, nasal airflow, apnea
Types of Manuscript: Original Research | Subject: Respiratory system

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