Volume 26, Issue 2 (June 2022)                   Physiol Pharmacol 2022, 26(2): 158-167 | Back to browse issues page

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Rezagholizadeh L, Ojarudi M, Moradi A, Salimnejad R, Khonakdar-Tarsi A, Matin S, et al . Protective effects of Cinnamomum zeylanicum and Zingiber officinale extract against CCl4-induced acute kidney injury in rats. Physiol Pharmacol 2022; 26 (2) :158-167
URL: http://ppj.phypha.ir/article-1-1742-en.html
Protective effects of Cinnamomum zeylanicum and Zingiber officinale extract against CCl4-induced acute kidney injury in rats
Lotfollah Rezagholizadeh , Masoud Ojarudi , Alireza Moradi , Ramin Salimnejad , Abbas Khonakdar-Tarsi , Somaieh Matin , Iraj Feizi , Alireza Mohammadnia , Mohammad Mazani
Abstract:   (2015 Views)
Introduction: The toxicity induced by toxic substances and medications is one of the principal reasons for acute kidney injury. The purpose of this study was to investigate the effect of Cinnamomum zeylanicum and Zingiber officinale extracts on the kidney of the rats intoxicated with carbon tetrachloride (CCl4). Methods: In this study, thirty-six Wistar rats randomly divided into six groups: I) control, II) cinnamon 25mg/kg + ginger 125mg/kg, III) CCl4, IV) CCl4+ cinnamon 50mg/kg, V) CCl4+ ginger 250mg/kg, VI) CCl4+ cinnamon 25mg/kg and ginger 125mg/kg. Cinnamomum zeylanicum and Zingiber officinale extracts were injected for 14 days. On the 14th day, the rats in the CCl4 and the pretreatment groups were administered with 1mg/kg of CCl4 and olive oil mixture (1:1 v/v). Forty-eight hours after the injection of CCl4, blood samples were taken to conduct subsequent biochemical tests. Also, the kidney removed and histological alterations as well as oxidative markers were investigated. Results: The administration of CCl4 increased the levels of urea, uric acid, creatinine and malondialdehyde; while decreased the levels of serum albumin, total protein, total antioxidant capacity and renal tissue antioxidant enzymes. Pretreatment with Cinnamomum zeylanicum and Zingiber officinale extracts, especially with a combination of them, led to considerable improvement in these values compared to the CCl4 group. Conclusion: The results suggest that hydroalcoholic extracts of Cinnamomum zeylanicum and Zingiber officinale, alone or simultaneously, have protective effects against free radicals produced during CCl4 metabolism.
Keywords: Cinnamomum zeylanicum, Zingiber officinale, Antioxidant, Carbon tetrachloride, Acute kidney injury.
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Type of Manuscript: Experimental research article | Subject: Renal Physiology/Pharmacology
References
1. Abd-Allah GA, El-Bakry KA, Bahnasawy MH, El-Khodary ES. Protective effects of curcumin and ginger on liver cirrhosis induced by carbon tetrachloride in rats. Int J Pharmacol 2016; 12: 361-9. [DOI:10.3923/ijp.2016.361.369]
2. Adewole S, Salako A, Doherty O, Naicker T. Effect of melatonin on carbon tetrachlorideinduced kidney injury in Wistar rats. Afr J Biomed Res 2007; 10. [DOI:10.4314/ajbr.v10i2.50619]
3. Aebi H. Catalase in vitro. Meth Enzymol 1984; 105: 121-6. [DOI:10.1016/S0076-6879(84)05016-3]
4. Alibakhshi T, Khodayar MJ, Khorsandi L, Rashno M, Zeidooni L. Protective effects of zingerone on oxidative stress and inflammation in cisplatin-induced rat nephrotoxicity. Biomed Pharmacother 2018; 105: 225-32. [DOI:10.1016/j.biopha.2018.05.085]
5. Bartosz G. Total antioxidant capacity. Adv Clin Chem 2003; 219-92. [DOI:10.1016/S0065-2423(03)37010-6]
6. Benzie IF, Strain JJ. The ferric reducing ability of plasma (FRAP) as a measure of "antioxidant power": the FRAP assay. Anal Biochem 1996; 239: 70-6. [DOI:10.1006/abio.1996.0292]
7. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976; 72: 248-54. [DOI:10.1016/0003-2697(76)90527-3]
8. Cachofeiro V, Goicochea M, De Vinuesa SG, Oubiña P, Lahera V, Luño J. Oxidative stress and inflammation, a link between chronic kidney disease and cardiovascular disease: New strategies to prevent cardiovascular risk in chronic kidney disease. Kidney Int 2008; 74: 4-S9. [DOI:10.1038/ki.2008.516]
9. Chávez-Morales RM, Jaramillo-Juárez F, Rodríguez-Vázquez ML, Martínez-Saldaña MC, Del Río FP, Garfias-López JA. The Ginkgo biloba extract (GbE) protects the kidney from damage produced by a single and low dose of carbon tetrachloride in adult male rats. Exp Toxicol Pathol 2017; 69: 430-4. [DOI:10.1016/j.etp.2017.04.003]
10. Chericoni S, Prieto JM, Iacopini P, Cioni P, Morelli I. In vitro activity of the essential oil of Cinnamomum zeylanicum and eugenol in peroxynitrite-induced oxidative processes. J Agric Food Chem 2005; 53: 4762-5. [DOI:10.1021/jf050183e]
11. Cifci A, Tayman C, Yakut HI, Halil H, Cakir E, Cakir U, et al. Ginger (Zingiber officinale) prevents severe damage to the lungs due to hyperoxia and inflammation. Turk J Med Sci 2018; 48: 892-900. [DOI:10.3906/sag-1803-223]
12. Eidi A, Mortazavi P, Bazargan M, Zaringhalam J. Hepatoprotective activity of cinnamon ethanolic extract against CCI4-induced liver injury in rats. Excli J 2012; 11: 495.
13. Ganie SA, Haq E, Masood A, Zargar MA. Amelioration of carbon tetrachloride induced oxidative stress in kidney and lung tissues by ethanolic rhizome extract of Podophyllum hexandrum in Wistar rats. J Med Plant Res 2010; 4: 1673-7.
14. Hismiogullari AA, Hismiogullari SE, Karaca O, Sunay FB, Paksoy S, Can M, et al. The protective effect of curcumin administration on carbon tetrachloride (CCl 4)-induced nephrotoxicity in rats. Pharmacol Rep 2015; 67: 410-6. [DOI:10.1016/j.pharep.2014.10.021]
15. Kang DH, Nakagawa T, Feng L, Watanabe S, Han L, Mazzali M, et al. A role for uric acid in the progression of renal disease. J Am Soc Nephrol 2002; 13: 2888-97. [DOI:10.1097/01.ASN.0000034910.58454.FD]
16. Kumar S, Kumar R, Dwivedi A, Pandey AK. In vitro antioxidant, antibacterial, and cytotoxic activity and in vivo effect of Syngonium podophyllum and Eichhornia crassipes leaf extracts on isoniazid induced oxidative stress and hepatic markers. BioMed Res Int 2014; 2014. [DOI:10.1155/2014/459452]
17. Lin L, Cui F, Zhang J, Gao X, Zhou M, Xu N, et al. Antioxidative and renoprotective effects of residue polysaccharides from Flammulina velutipes. Carbohydr Polym 2016; 146: 388-95. [DOI:10.1016/j.carbpol.2016.03.071]
18. Maghsoudi S, Gol A, Dabiri S, Javadi A. Preventive effect of ginger (Zingiber officinale) pretreatment on renal ischemia-reperfusion in rats. Eur Surg Res 2011; 46: 45-51. [DOI:10.1159/000321704]
19. Mahmoud MF, Diaai AA, Ahmed F. Evaluation of the efficacy of ginger, Arabic gum, and Boswellia in acute and chronic renal failure. Ren Fail 2012; 34: 73-82. [DOI:10.3109/0886022X.2011.623563]
20. Mazani M, Mahmoodzadeh Y, Asl MM, Banaei S, Rezagholizadeh L, Mohammadnia A. Renoprotective effects of the methanolic extract of Tanacetum parthenium against carbon tetrachloride-induced renal injury in rats. Avicenna J Phytomed 2018; 8: 370.
21. Mazani M, Ojarudi M, Banaei S, Salimnejad R, Latifi M, Azizi H, et al. The protective effect of cinnamon and ginger hydro‐alcoholic extract on carbon tetrachloride‐induced testicular damage in rats. Andrologia 2020; 52: 13651. [DOI:10.1111/and.13651]
22. Ogeturk M, Kus I, Colakoglu N, Zararsiz I, Ilhan N, Sarsilmaz M. Caffeic acid phenethyl ester protects kidneys against carbon tetrachloride toxicity in rats. J Ethnopharmacol 2005; 97: 273- 80. [DOI:10.1016/j.jep.2004.11.019]
23. Preethi KC, Kuttan R. Hepato and reno protective action of Calendula officinalis L. Flower Extract. 2009.
24. Radulović NS, Randjelović PJ, Stojanović NM, Ilić IR, Miltojević AB, Stojković MB, et al. Effect of two esters of N-methylanthranilic acid from Rutaceae species on impaired kidney morphology and function in rats caused by CCl4. Life Sci 2015; 135: 110-7. [DOI:10.1016/j.lfs.2015.05.022]
25. Rajesh MG, Latha MS. Protective activity of Glycyrrhiza glabra Linn. on carbon tetrachlorideinduced peroxidative damage. Indian J Pharmacol 2004; 36: 284.
26. Shahbazi F, Dashti-Khavidaki S, Khalili H, Lessan-Pezeshki M. Potential renoprotective effects of silymarin against nephrotoxic drugs: a review of literature. J Pharm Pharm Sci 2012; 15: 112- 23. [DOI:10.18433/J3F88S]
27. Sharafeldin K, Rizvi MR. Effect of traditional plant medicines (Cinnamomum zeylanicum and Syzygium cumini) on oxidative stress and insulin resistance in streptozotocin-induced diabetic rats. J Basic & Appl Zool 2015; 72: 126-34. [DOI:10.1016/j.jobaz.2015.09.002]
28. Sharma UK, Kumar R, Gupta A, Ganguly R, Pandey AK. Renoprotective effect of cinnamaldehyde in food color induced toxicity. 3 Biotech 2018; 8: 1-5. [DOI:10.1007/s13205-018-1241-z]
29. Shirpoor A, Rezaei F, Fard AA, Afshari AT, Gharalari FH, Rasmi Y. Ginger extract protects rat's kidneys against oxidative damage after chronic ethanol administration. Biomed Pharmacother 2016; 84: 698-704. [DOI:10.1016/j.biopha.2016.09.097]
30. Shokoohi M, Soltani M, Abtahi-Eivary SH, Niazi V, Poor MJ, Ravaei H, et al. Effect of hydro-- alcoholic extract of Olea europaea on apoptosis--related genes and oxidative stress in a rat model of torsion/detorsion--induced ovarian damage. Asian Pac J Reprod 2019; 8: 148. [DOI:10.4103/2305-0500.262831]
31. Subasini U, Thenmozhi S, Rajamanickam GV, Dwivedi GD. Reno-protective and Membrane Stabilizing Effect of Dioscorea bulbifera L. in CCL4 Induced Toxicity in Rats. Am J Life Sci Res 2015; 3.
32. Sudjarwo SA, Giftania Wardani Sudjarwo K. Protective effect of curcumin on lead acetateinduced testicular toxicity in Wistar rats. Res Pharm Sci 2017; 12: 381. [DOI:10.4103/1735-5362.213983]
33. Tiong HY, Huang P, Xiong S, Li Y, Vathsala A, Zink D. Drug-induced nephrotoxicity: clinical impact and preclinical in vitro models. Mol pharm 2014; 11: 1933-48. [DOI:10.1021/mp400720w]
34. Trujillo J, Chirino YI, Molina-Jijón E, Andérica-Romero AC, Tapia E, Pedraza-Chaverrí J. Renoprotective effect of the antioxidant curcumin: Recent findings. Redox Biol 2013; 1: 448-56. [DOI:10.1016/j.redox.2013.09.003]
35. Uchiyama M, Mihara M. Determination of malonaldehyde precursor in tissues by thiobarbituric acid test. Anal Biochem 1978; 86: 271-8. [DOI:10.1016/0003-2697(78)90342-1]
36. Yanishlieva NV, Marinova E, Pokorný J. Natural antioxidants from herbs and spices. Eur J Lipid Sci Technol 2006; 108: 776-93. [DOI:10.1002/ejlt.200600127]
37. Yilmaz-Ozden T, Can A, Karatug A, Pala-Kara Z, Okyar A, Bolkent S. Carbon tetrachlorideinduced kidney damage and protective effect of Amaranthus lividus L. in rats. Toxicol Ind Health 2016; 32: 1143-52. [DOI:10.1177/0748233714555390]
38. Yılmaz N, Seven B, Timur H, Yorgancı A, İnal HA, Kalem MN, et al. Ginger (zingiber officinale) might improve female fertility: A rat model. J Chin Med Assoc 2018; 81: 905-11. [DOI:10.1016/j.jcma.2017.12.009]
39. Yoshioka H, Usuda H, Nonogaki T, Onosaka S. Carbon tetrachloride-induced lethality in mouse is prevented by multiple pretreatment with zinc sulfate. J Toxicol Sci 2016; 41: 55-63. [DOI:10.2131/jts.41.55]
40. Yousefi H, Ahmadiasl N, Salimnejad R, Bagheri E, Roshangar L, Alihemmati A. Effects of renal ischemia-reperfusion on biochemical factors and histopathological alterations in the liver of male rats. Physiol Pharmacol 2019; 23: 44-50.
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