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Abstract:   (118 Views)
Introduction: The positive effects of exercise on the age-related impairment of learning and memory are well-established. There is no clear report concerning the effects of pre-adolescence exercise on cognitive function during adulthood. Methods: Four-week-old male Wistar rats were divided randomly into the non-swimmer (control (n=20)) and swimmer (n=20). The swimmer group was trained to swim 30 min/day, 6 days a week, for 6 weeks. One week after the last swimming day, all rats were submitted to behavioral tests (passive avoidance learning and Radial Maze). Finally, population spike (PS) amplitude and the slope of the excitatory postsynaptic potentials (fEPSPs) of the LTP were recorded in the hippocampal dentate gyrus. Results: Swimming exercise caused a decrease in the number of trials in the passive avoidance test. Furthermore, swimming decreased the number of working memory and reference memory errors in the radial maze task. In the radial maze task, the two groups showed the same learning ability in finding the baited food arms on the 15th day. The results of the retrieval test indicated that the number of total memory errors (P<0.01) and working memory errors (P<0.01) in the swimmer group was significantly less than the non-swimmer group. Exercise also enhanced both the PS amplitude and the fEPSP slope. Conclusion: These findings suggest that swimming exercise can improve memory through improved synaptic plasticity in rats.
 
     
Types of Manuscript: Experimental research article | Subject: Blood and Immune System

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