Volume 26, Issue 3 (September 2022)                   Physiol Pharmacol 2022, 26(3): 288-298 | Back to browse issues page

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Taslimi Z, Sarihi A, Karimi S, Haghparast A. Changes in the electrical activity of prefrontal neurons following methamphetamine-induced conditioned place preference in the rat. Physiol Pharmacol. 2022; 26 (3) :288-298
URL: http://ppj.phypha.ir/article-1-1764-en.html
Abstract:   (845 Views)
Introduction: Methamphetamine (METH) addiction is an epidemic-growing problem globally. Studies confirmed a solid linkage between the prefrontal cortex (PFC) and drug seeking. The present study aimed to investigate PFC neural activity changes after injection of METH following METH-induced conditioned place preference (CPP) in the rats. Methods: After the development of CPP (0.5mg/kg METH for three days, SC), in vivo single-unit recordings were carried out the day after the post-test (post-conditioning day). On recording day, after stabilization and baseline recording (a 10-min period), the injection of METH (0.5mg/kg, SC) was performed and then, PFC neural activity was recorded for a 30-min period. Results: The results revealed that the injection of METH on the post-conditioning test significantly increases PFC neurons’ firing rate in animals that received METH during the CPP paradigm. Conclusion: It seems that maybe, PFC neurons appear to be implicated in the associated METH reward pathway and repeated exposure to METH affected the sensitivity of neurons in this area.
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