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Abstract:   (276 Views)
Methamphetamine (METH) addiction is an epidemic-growing problem globally. Studies confirmed a solid linkage between the prefrontal cortex (PFC) and drug-seeking. The present study aimed to investigate changes in PFC neural activity after injection of METH during METH-induced conditioned place preference (CPP) in the rats. After the development of CPP (METH; 0.5 mg/kg for three days, s.c.), in vivo, single-unit recordings were carried out the day after the post-test (Post-conditioning day). On recording day, after stabilization and baseline recording (a 10-min period), the injection of METH (0.5 mg/kg; s.c.) was performed and then, PFC neural action was recorded for a 30-min period. The results revealed that the injection of METH on the post-conditioning test significantly increases PFC neuronschr('39') firing rate in animals that received METH during the CPP paradigm. It seems that PFC neurons appear to be involved in the METH reward pathway, and repeated exposure to METH altered the sensitivity of neurons in this area.
Types of Manuscript: Original Research | Subject: Electrophysiology

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