Volume 25, Issue 3 (September 2021)                   Physiol Pharmacol 2021, 25(3): 193-205 | Back to browse issues page

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Peyvandi A A, Niknazar S, Zare Mehrjerdi F, Abbaszadeh H, Khoshsirat S, Peyvandi M. Molecular mechanisms and signaling pathways involved in immunopathological events of COVID-19. Physiol Pharmacol 2021; 25 (3) :193-205
URL: http://ppj.phypha.ir/article-1-1789-en.html
Abstract:   (2482 Views)
Introduction: COVID-19, a novel coronavirus that causes severe acute respiratory syndrome (SARS-CoV-2), is currently regarded as the most serious viral disease. During corona infection, viruses bind to host proteins and employ a variety of cellular pathways for their own purposes. Cell signaling is important for the regulation of cellular function. SARS-CoV-2 infection alters multiple signal transduction pathways that are critical for cell survival. The virus causes a severe and prolonged period of hypercytokinemia with misusing of these signaling cascades. Hyperactivation of the host immune system after infection with SARS-CoV-2 is the main cause of death in COVID-19 patients. Thus, to develop effective therapeutic approaches, it is necessary to first understand the problem and the underlying molecular pathways implicated in host immunological function/dysfunction. A number of intracellular signaling cascades have been implicated in infected cell pathways, including MAPK pathway, NF-κB pathway, JAK–STAT signaling pathway, PI3K/AKT/mTOR pathway and TLRI signaling cascades. Here, we have presented the molecular insights on the potential mechanisms involved in immunopathological events of COVID-19.
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Type of Manuscript: Review | Subject: Cell, Stem Cell and Cancer

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