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Abstract:   (5284 Views)

Introduction: Two of the most important ion channels of smooth muscle membrane is L-type and T-type calcium channels. Calcium required for smooth muscle contraction and cell membrane depolarization is carried out by L-type calcium channel and T-type calcium channel, respectively.
Methods: In this model, 1200 cells have been used to simulate the smooth muscle of the gastric wall. In this paper, the effect of blockage of 10, 50, 90, and 100% of L-type and T-type calcium channels on the spatiotemporal wavefront propagation in the human gastric wall smooth muscle cells has been simulated separately.
Results: The results showed that the greatest effect of blockage of both channels on the slow-wave was related to complete blockage. The greatest effect of the L-type calcium channel on reducing the membrane potential of spike and plateau phases was -3.4% and -0.8%, respectively. The T-type calcium channel reduced the spike and resting membrane potential by -1.8% and -0.9%, respectively. In addition, it was found that the effect of the L-type calcium channel in reducing contraction was greater than that of the T-type calcium channel. This means that with more blockage of calcium channels, the membrane potential of slow-wave phases and the muscle contraction decreased compared to the physiological state.
Conclusion: Gastrointestinal tract motility disorders and smooth muscle contraction can be controlled by blocking ion channels in electrophysiological models.

Types of Manuscript: Experimental research article | Subject: Blood and Immune System

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