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Milad Qaderi 
, Ahmad Enferadi Qazanabad , Peyman Khademi , Parvin Mahdavi , Seyyed Meysam Abtahi Froushani
, Ahmad Enferadi Qazanabad , Peyman Khademi , Parvin Mahdavi , Seyyed Meysam Abtahi Froushani
Abstract: (491 Views)
Introduction: The anti-inflammatory and immunomodulatory properties of tarragon have been mentioned. Here, we checked the effects of an aqueous extract of the tarragon plant in a rat model of ulcerative colitis.
Methods: Intra-rectal enema of 2 ml acetic acid (4%) was used to induce ulcerative colitis Wistar rats. Experimental groups received sulfasalazine (2 mg/kg) or tarragon aqueous extract (100 mg/kg) orally for ten consecutive days. After ten days, the animals were euthanized and examined in terms of disease activity index (DAI), production of inflammatory mediators, and pro-inflammatory mediators in the intestinal tissue.
Results: Both extract and sulfasalazine treatment methods were effective in reducing the disease severity index in experimental ulcerative colitis. Malondialdehyde intensity, nitric oxide level and myeloperoxidase activity regressed in the colon of animals treated with tarragon aqueous extract more than the group treated with sulfasalazine. However, sulfasalazine significantly reduced TNF-α and IL-1 levels compared to tarragon aqueous extract. There was no statistical difference in IL-6 and PGE2 reduction between the two groups.
Conclusion: These findings suggested that the aqueous extract of tarragon may be applied as a natural resource to control ulcerative colitis.
Methods: Intra-rectal enema of 2 ml acetic acid (4%) was used to induce ulcerative colitis Wistar rats. Experimental groups received sulfasalazine (2 mg/kg) or tarragon aqueous extract (100 mg/kg) orally for ten consecutive days. After ten days, the animals were euthanized and examined in terms of disease activity index (DAI), production of inflammatory mediators, and pro-inflammatory mediators in the intestinal tissue.
Results: Both extract and sulfasalazine treatment methods were effective in reducing the disease severity index in experimental ulcerative colitis. Malondialdehyde intensity, nitric oxide level and myeloperoxidase activity regressed in the colon of animals treated with tarragon aqueous extract more than the group treated with sulfasalazine. However, sulfasalazine significantly reduced TNF-α and IL-1 levels compared to tarragon aqueous extract. There was no statistical difference in IL-6 and PGE2 reduction between the two groups.
Conclusion: These findings suggested that the aqueous extract of tarragon may be applied as a natural resource to control ulcerative colitis.
Type of Manuscript: Experimental research article |
Subject:
Gastrointestinal Physiology/Pharmacology
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