Volume 28, Issue 2 (July 2024)
Physiol Pharmacol 2024, 28(2): 180-189 |
Back to browse issues page
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Qaderi M, Enferadi Qazanabad A, Khademi P, Mahdavi P, Abtahi Froushani S M. Comparing the efficacy of sulfasalazine and an aqueous extract of tarragon in an experimental model of ulcerative colitis. Physiol Pharmacol 2024; 28 (2) : 8
URL: http://ppj.phypha.ir/article-1-2200-en.html
URL: http://ppj.phypha.ir/article-1-2200-en.html
Milad Qaderi 
, Ahmad Enferadi Qazanabad , Peyman Khademi , Parvin Mahdavi , Seyyed Meysam Abtahi Froushani
, Ahmad Enferadi Qazanabad , Peyman Khademi , Parvin Mahdavi , Seyyed Meysam Abtahi Froushani
Abstract: (1547 Views)
Introduction: The anti-inflammatory and immunomodulatory properties of tarragon have been noted. Here, we examined the effects of an aqueous extract of the tarragon plant in a rat model of ulcerative colitis.
Methods: Ulcerative colitis was induced in Wistar rats using a 2 ml acetic acid (4%) intrarectal enema. Experimental groups received sulfasalazine (2 mg/kg) or tarragon aqueous extract (100 mg/kg) orally for ten consecutive days. After ten days, the animals were euthanized and evaluated for disease activity index (DAI), production of inflammatory and pro-inflammatory mediators in the intestinal tissue.
Results: Both the tarragon aqueous extract and sulfasalazine treatments were effective in reducing the disease severity index in experimental ulcerative colitis. Malondialdehyde intensity, nitric oxide level, and myeloperoxidase activity regressed in the colon of animals treated with the tarragon aqueous extract more than in the group treated with sulfasalazine. However, sulfasalazine significantly reduced TNF-α and IL-1 levels compared to the tarragon aqueous extract. There was no statistical difference in IL-6 and PGE2 reduction between the two groups.
Conclusion: These findings suggested that the aqueous extract of tarragon may be applied as a natural resource to control ulcerative colitis.
Article number: 8
Type of Manuscript: Experimental research article |
Subject:
Gastrointestinal Physiology/Pharmacology
References
1. Abtahi Froushani S M, Mashouri S. The beneficial effects of hypiran in ameliorating rat model of ulcerative colitis. Zahedan Journal of Research in Medical Sciences 2018; 20. [DOI:10.5812/zjrms.58919]
2. Abtahi Froushani S M, Zarei L, Ghaleh H E G, Motlagh B M. Estragole and methyl-eugenol-free extract of Artemisia dracunculus possesses immunomodulatory effects. Avicenna Journal of Phytomedicine 2016; 6: 526.
3. Aglarova A, Zilfikarov I, Severtseva O. Biological characteristics and useful properties of tarragon (Artemisia dracunculus L.). Pharmaceutical Chemistry Journal 2008; 42: 81-86. [DOI:10.1007/s11094-008-0064-3]
4. Al-Rejaie S S, Abuohashish H M, Al-Enazi M M, Al-Assaf A H, Parmar M Y, Ahmed M M. Protective effect of naringenin on acetic acid-induced ulcerative colitis in rats. World Journal of Gastroenterology 2013a; 19: 5633. [DOI:10.3748/wjg.v19.i34.5633]
5. Al-Rejaie S S, Aleisa A M, Sayed-Ahmed M M, Al-Shabanah O A, Abuohashish H M, Ahmed M M, et al. Protective effect of rutin on the antioxidant genes expression in hypercholestrolemic male Westar rat. BMC Complementary and Alternative Medicine 2013b; 13: 136. [DOI:10.1186/1472-6882-13-136]
6. D’haens G. Systematic review: second-generation vs. conventional corticosteroids for induction of remission in ulcerative colitis. Alimentary Pharmacology Therapeutics 2016; 44: 1018-1029. [DOI:10.1111/apt.13803]
7. de Carvalho L R, de Brito T V, Junior J S d C, Júnior G J D, de Aguiar Magalhãres D, Sousa S G, et al. Epiisopiloturine, an imidazole alkaloid, reverses inflammation and lipid peroxidation parameters in the Crohn disease model induced by trinitrobenzenosulfonic acid in Wistar rats. Biomedicine Pharmacotherapy 2018; 102: 278-285. [DOI:10.1016/j.biopha.2018.03.090]
8. de Ridder L, Turner D, Wilson D C, Koletzko S, Martin-de-Carpi J, Fagerberg U L, et al. Malignancy and mortality in pediatric patients with inflammatory bowel disease: a multinational study from the porto pediatric IBD group. Inflammatory Bowel Diseases 2014; 20: 291-300. [DOI:10.1097/01.MIB.0000439066.69340.3c]
9. De Vincenzi M, Silano M, Maialetti F, Scazzocchio B. Constituents of aromatic plants: II. Estragole. Fitoterapia 2000; 71: 725-729. [DOI:10.1016/S0367-326X(00)00153-2]
10. Dubska L, Literak I, Kocianova E, Taragelova V, Sychra O. Differential role of passerine birds in distribution of Borrelia spirochetes, based on data from ticks collected from birds during the postbreeding migration period in Central Europe. Applied and Environmental Microbiology 2009; 75: 596-602. [DOI:10.1128/AEM.01674-08]
11. Ekiert H, Świątkowska J, Knut E, Klin P, Rzepiela A, Tomczyk M, et al. Artemisia dracunculus (Tarragon): A review of its traditional uses, Phytochemistry and Pharmacology. Frontiers in Pharmacology 2021; 12. [DOI:10.3389/fphar.2021.653993]
12. Esmaeilnejad B, Abtahi Froushani S, Tehrani A, Esmaeili Gouvarchin Ghaleh H, Moshrefzadeh F. Effect of Fasciola hepatica on acetic acid induced ulcerative colitis in rat model. Journal of Fasa University of Medical Sciences 2018; 8: 1136-1145.
13. Gupta M, Mishra V, Gulati M, Kapoor B, Kaur A, Gupta R, et al. Natural compounds as safe therapeutic options for ulcerative colitis. Inflammopharmacology 2022; 30: 397-434. [DOI:10.1007/s10787-022-00931-1]
14. Hauso Ø, Martinsen T C, Waldum H. 5-Aminosalicylic acid, a specific drug for ulcerative colitis. Scandinavian Journal of Gastroenterology 2015; 50: 933-941. [DOI:10.3109/00365521.2015.1018937]
15. Hindryckx P, Jairath V, D’haens G. Acute severe ulcerative colitis: from pathophysiology to clinical management. Nature Reviews Gastroenterology Hepatology 2016; 13: 654-664. [DOI:10.1038/nrgastro.2016.116]
16. Kordali S, Kotan R, Mavi A, Cakir A, Ala A, Yildirim A. Determination of the chemical composition and antioxidant activity of the essential oil of Artemisia dracunculus and of the antifungal and antibacterial activities of Turkish Artemisia absinthium, A. dracunculus, Artemisia santonicum, and Artemisia spicigera essential oils. Journal of agricultural food chemistry 2005; 53: 9452-9458. [DOI:10.1021/jf0516538]
17. Landgren A M, Landgren O, Gridley G, Dores G M, Linet M S, Morton L M. Autoimmune disease and subsequent risk of developing alimentary tract cancers among 4.5 million US male veterans. Cancer 2011; 117: 1163-1171. [DOI:10.1002/cncr.25524]
18. Liu B, Li S, Sui X, Guo L, Liu X, Li H, et al. Root extract of Polygonum cuspidatum Siebold & Zucc. ameliorates DSS-induced ulcerative colitis by affecting NF-kappaB signaling pathway in a mouse model via synergistic effects of polydatin, resveratrol, and emodin. Frontiers in Pharmacology 2018; 9: 347. [DOI:10.3389/fphar.2018.00347]
19. Low D, Nguyen D D, Mizoguchi E. Animal models of ulcerative colitis and their application in drug research. Drug Design, Development Therapy 2013: 1341-1357. [DOI:10.2147/DDDT.S40107]
20. Majdan M, Kiss A K, Hałasa R, Granica S, Osińska E, Czerwińska M E. Inhibition of neutrophil functions and antibacterial effects of tarragon (Artemisia dracunculus L.) infusion-phytochemical characterization. Frontiers in Pharmacology 2020; 11: 947.
21. Mashhouri S, Abtahi Froushani S M, Tehrani A A. Non-Adherent Bone marrow-derived mesenchymal stem cells ameliorate clinical manifestations and inflammation in an experimental model of ulcerative colitis in rats. Iranian Journal of Medical Sciences 2020; 45: 341.
22. Menichini F, Conforti F, Rigano D, Formisano C, Piozzi F, Senatore F. Phytochemical composition, anti-inflammatory and antitumour activities of four Teucrium essential oils from Greece. Food Chemistry 2009; 115: 679-686. [DOI:10.1016/j.foodchem.2008.12.067]
23. Nageeb A, Al-Tawashi A, Mohammad Emwas A-H, Abdel-Halim Al-Talla Z, Al-Rifai N. Comparison of Artemisia annua bioactivities between traditional medicine and chemical extracts. Current Bioactive Compounds 2013; 9: 324-332. [DOI:10.2174/157340720904140404151439]
24. Obolskiy D, Pischel I, Feistel B, Glotov N, Heinrich M. Artemisia dracunculus L.(tarragon): a critical review of its traditional use, chemical composition, pharmacology, and safety. Journal of Agricultural Food Chemistry 2011; 59: 11367-11384. [DOI:10.1021/jf202277w]
25. Orsonneau J, Douet P, Massoubre C, Lustenberger P, Bernard S. An improved pyrogallol red-molybdate method for determining total urinary protein. Clinical chemistry 1989; 35: 2233-2236. [DOI:10.1093/clinchem/35.11.2233]
26. Osanloo M, Firooziyan S, Abdollahi A, Hatami S, Nematollahi A, Elahi N, et al. Nanoemulsion and nanogel containing Artemisia dracunculus essential oil; larvicidal effect and antibacterial activity. BMC Research Notes 2022; 15: 276. [DOI:10.1186/s13104-022-06135-8]
27. Salamatian M, Mohammadi V, Abtahi Froushani S M. Ameliorative effects of aqueous cinnamon extract on ulcerative colitis in rats. Physiology Pharmacology 2019; 23: 140-149.
28. Saraiva R A, Araruna M K, Oliveira R C, Menezes K D, Leite G O, Kerntopf M R, et al. Topical anti-inflammatory effect of Caryocar coriaceum Wittm. (Caryocaraceae) fruit pulp fixed oil on mice ear edema induced by different irritant agents. Journal of Ethnopharmacology 2011; 136: 504-510. [DOI:10.1016/j.jep.2010.07.002]
29. Sayyah M, Nadjafnia L, Kamalinejad M. Anticonvulsant activity and chemical composition of Artemisia dracunculus L. essential oil. Journal of Ethnopharmacology 2004; 94: 283-287. [DOI:10.1016/j.jep.2004.05.021]
30. Schepetkin I A, Özek G, Özek T, Kirpotina L N, Khlebnikov A I, Klein R A, et al. Neutrophil immunomodulatory activity of farnesene, a component of Artemisia dracunculus essential oils. Pharmaceuticals 2022; 15: 642. [DOI:10.3390/ph15050642]
31. Shahid M, Raish M, Ahmad A, Bin Jardan Y A, Ansari M A, Ahad A, et al. Sinapic acid ameliorates acetic acid-induced ulcerative colitis in rats by suppressing inflammation, oxidative stress, and apoptosis. Molecules 2022; 27. [DOI:10.3390/molecules27134139]
32. Shahrivari S, Alizadeh S, Ghassemi-Golezani K, Aryakia E. A comprehensive study on essential oil compositions, antioxidant, anticholinesterase and antityrosinase activities of three Iranian Artemisia species. Scientific Reports 2022; 12: 7234. [DOI:10.1038/s41598-022-11375-6]
33. Shahriyary L, Yazdanparast R. Inhibition of blood platelet adhesion, aggregation and secretion by Artemisia dracunculus leaves extracts. Journal of Ethnopharmacology 2007; 114: 194-198. [DOI:10.1016/j.jep.2007.07.029]
34. Shibrya E E, Rashed R R, Abd El Fattah M A, El-Ghazaly M A, Kenawy S A. Apigenin and exposure to low dose gamma radiation ameliorate acetic acid-induced ulcerative colitis in rats. Dose-Response 2023; 21: 15593258231155787. [DOI:10.1177/15593258231155787]
35. Visavadiya N P, Soni B, Dalwadi N, nutrition. Evaluation of antioxidant and anti-atherogenic properties of Glycyrrhiza glabra root using in vitro models. International Journal of Food Sciences 2009; 60: 135-149. [DOI:10.1080/09637480902877998]
36. Wang Y, Parker C E, Feagan B G, MacDonald J K. Oral 5-aminosalicylic acid for maintenance of remission in ulcerative colitis. Cochrane Database of Systematic Reviews 2016. [DOI:10.1002/14651858.CD000544.pub4]
37. Weinoehrl S, Feistel B, Pischel I, Kopp B, Butterweck V. Comparative evaluation of two different Artemisia dracunculus L. cultivars for blood sugar lowering effects in rats. hytotherapy Research 2012; 26: 625-629. [DOI:10.1002/ptr.3605]
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
