Histamine directly interacts with airways smooth muscles to initiate contraction. This occurs even at low concentrations among individuals predisposed to increase airways inflammation. Method: A Digital Vitalograph, Nebulizer, Histamine, was used in this research. A total number of  one hundred and sixty subjects were selected and categorized into two groups; Grp1 (Test) and Grp2 (Control)  subjects, each group contained eighty (80) subjects. Grp1 comprised of occupationally exposed Vulcanizers and Grp2 was selected students from University of Calabar that served as Control. Both groups comprised of young male subjects of equal age(20-40 years), devoid of pre-existing respiratory disorders or on any medication(s). Demographic parameters were used to obtain sufficient information for overall analysis. Lung parameters (FVC, FEV₁, PEFR and FEV_1%) were evaluated using a Vitalograph  Spirometer. Results: Basal measurement showed that Group1 had moderate decrease in lung volumes (FVC, FEV₁, PEFR and FEV_1%) of 65 subjects (representing 81.25%) and mild decrease in 15 subjects (18.75%); all the subjects in Group2 showed mild decrease in  lung volumes. Inhalation of histamine mist of different concentrations showed that Group1 had severe decrease in lung volumes of 70 subjects (87.5%) and mild decrease in 10 subjects (12.5%). All Subjects in Group2 showed mild decrease in lung volumes. Conclusion: Histamine provocative test helps to evaluates asthma sign and symptoms. Airways Hyper reactivity is associated with inflammation as a consequence of airways hyperreflexia. Vulcanizers has retrogressive impact on their airways which manifests with hyper response an indication for asthma signs.