Volume 28, Issue 3 (September 2024)
Physiol Pharmacol 2024, 28(3): 338-350 |
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mashayekhi-sardoo H, Vasegh A, Razavi B M, Imenshahidi M. Comparing the Analgesic and Anti-Ulcer Properties of Green Tea Aqueous Extract with Licofelone. Physiol Pharmacol 2024; 28 (3) : 10
URL: http://ppj.phypha.ir/article-1-2286-en.html
URL: http://ppj.phypha.ir/article-1-2286-en.html
Abstract: (1676 Views)
Introduction: Green tea possesses gastroprotective effects via different mechanisms including lipoxygenase inhibition. We compared its protective effects with licofelone (as a potent lipoxygenase inhibitor) on reducing the incidence of gastric ulcers caused by indomethacin.
Methods: 48 rats received an aqueous extract of green tea (GTAE; 50, 100, and 200 mg/kg), licofelone (30 mg/kg), zileuton (100 mg/kg), or 0.18% Tween 80 in the presence of indomethacin (100 mg/kg). Two groups received only GTAE (200 mg/kg) or indomethacin (100 mg/kg). The gastric ulcer index and Malondialdehyde (MDA) in gastric tissues were evaluated. To investigate the analgesic effect in acute and chronic phases, 24 rats received GTAE (200 mg/kg), licofelone (30 mg/kg), indomethacin (30 mg/kg), or 0.18% Tween 80 in the presence of formalin (2.5%). The behavior of rats was monitored for 30 minutes (minutes 0 to 5 and 25 to 30) for licking and biting feet and tails.
Results: Indomethacin (100 mg/kg) produced clear macroscopic lesions compared to the control group. GTAE (100 and 200 mg/kg), licofelone, and Zileuton showed a significant decrease in wound score compared to indomethacin. GTAE (100 mg/kg and 200), licofelone, and zileuton displayed a significant decrease in the MDA content of gastric tissue compared to the indomethacin group. Notably, GTAE exerted greater benefits than licofelone. Besides, GTAE (200 mg/kg) showed a significant decrease observed in both acute and chronic stages of pain compared to licofelone (30 mg/kg).
Conclusion: GTAE (200 mg/kg) possesses anti-ulcer and analgesic effects similar to licofelone. The exact mechanism is probably via inhibition of lipoxygenase (LOX) and antioxidant effects.
Article number: 10
Type of Manuscript: Experimental research article |
Subject:
Gastrointestinal Physiology/Pharmacology
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