Volume 10, Issue 3 (Fall 2006)                   Physiol Pharmacol 2006, 10(3): 183-189 | Back to browse issues page

XML Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Abbasi zadeh Z, Kesmati M, Fathi Moghaddam H. Study of benzodiazepine like effect of Matricaria recutita extract on acute pain in the presence and absence of paragigantocellularis nucleus in adult male rats . Physiol Pharmacol 2006; 10 (3) :183-189
URL: http://ppj.phypha.ir/article-1-273-en.html
Study of benzodiazepine like effect of Matricaria recutita extract on acute pain in the presence and absence of paragigantocellularis nucleus in adult male rats
Zahra Abbasi zadeh , Mahnaz Kesmati , Hadi Fathi Moghaddam
Abstract:   (13676 Views)
Introduction: In this study the effect of Matricaria recutita extract on acute pain in the presence and absence of flumazenil (antagonist of benzodiazepine) and lesioned paragigantocellularis (PGi) nucleus was investigated. Method: Wistar male rats (250±20 g) were used. Animals were grouped randomly into intact, sham and bilateral lesion of PGi nucleus. Intact and lesioned animals, each divided into 4 subgroups which received saline, M. recutita hydro-alcoholic extract (25 mg/kg), flumazenil (1 mg/kg) and flumazenil + M. recutita. Hot plate test were used for pain thereshold evaluation. Results: Results showed that: In intact animals M. recutita induced analgesic effect but flumazenil had significant hyperalgesic effect. In these animals flumazenil prevented the analgesic effects of M. recutita. Lesion of PGi induced significant hyperalgesia. M. recutita in absence of PGi nucleus showed significant analgesic effect and flumazenil increased pain sensation and caused significant hyperalgesia. The analgesic effect of M. recutita attenuated by flumazenil in absence of PGi nucleus. Conclusion: It seems that PGi nucleus involves in pain modulation but analgesic effect of M. recutita that may be via the benzodiazepine-like activity of some its components does not interact with PGi nucleus.
Keywords: Matricaria recutita, Paragigantocellularis nucleus, Flumazenil, Hot plate.
Full-Text [PDF 244 kb]   (2430 Downloads)    
Type of Manuscript: Experimental research article |
Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.