Volume 11, Issue 1 (Spring 2007)                   Physiol Pharmacol 2007, 11(1): 10-18 | Back to browse issues page

XML Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Sadegh M, Mirnajafi-Zadeh J, Javan M, Fathollahi Y, Mohammad-Zadeh M, Jahanshahi A et al . The role of galanin receptors in anticonvulsant effect of low frequency stimulations on acquisition of perforant path kindled seizures in rats . Physiol Pharmacol 2007; 11 (1) :10-18
URL: http://ppj.phypha.ir/article-1-375-en.html
The role of galanin receptors in anticonvulsant effect of low frequency stimulations on acquisition of perforant path kindled seizures in rats
Mehdi Sadegh , Javad Mirnajafi-Zadeh , Mohammad Javan , Yaghoub Fathollahi , Mohammad Mohammad-Zadeh , Ali Jahanshahi , Zahra Deljo
Abstract:   (13699 Views)
Introduction: Low-frequency stimulation (LFS) has a delaying effect on kindled seizures acquisition. In the present study we examined the role of galanin receptors in the inhibitory effects of LFS on kindled seizures induced by electrical stimulation of perforant path. Methods: Animals were stimulated daily at the AD threshold intensity with a rapid kindling procedure. LFS was applied immediately after cessation of each kindling stimulation. M35 (0.5 and 1.0 nM per site), a nonselective galanin receptor antagonist, was microinjected daily into the dentate gyrus before the beginning of stimulation protocol and behavioral seizure stages and afterdischarge durations were recorded. Results: LFS application had a suppressive effect on the kindling rate. It significantly increased the number of stimulations needed to reach seizure stages 3, 4 and 5. LFS also decreased the cumulative afterdischarge duration during the days of stimulation. Intra-dentate gyrus microinjection of M35 reduced the inhibitory effect of LFS on kindling rate, significantly. Conclusion: These data indicate that galanin receptors may have a role in mediating part of the inhibitory effects of LFS on perforant path kindled seizures.
Keywords: Seizure, Low frequency stimulation, Galanin, Dentate gyrus, Rapid kindling.
Full-Text [PDF 296 kb]   (2045 Downloads)    
Type of Manuscript: Experimental research article |
Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.