Volume 11, Issue 1 (Spring 2007)
Physiol Pharmacol 2007, 11(1): 30-37 |
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Poorrahimi A M, Sheiban V, Abbasnejad M, Mazhari S. Effects of REM sleep deprivation during pregnancy on spatial learning of adult male offspring of rats . Physiol Pharmacol 2007; 11 (1) :30-37
URL: http://ppj.phypha.ir/article-1-377-en.html
URL: http://ppj.phypha.ir/article-1-377-en.html
Abstract: (15440 Views)
Introduction: There are several evidences that show various environmental stresses during pregnancy, affect
physiological behavior of the offspring. In this study the effects of REM (Rapid Eye Movement) sleep deprivation of
pregnant rats on spatial learning of adult male offspring by Morris water maze were investigated.
Methods: Water tank technique was used for inducing REM sleep deprivation. Pregnant rats were deprived for 3
days (E14, E15 and E16 or E17, E18 and E19) on a small platform (diameter: 5.5 cm) or a large platform (diameter: 19
cm) (sham). Undeprived (control) pregnant rats offspring were also used. Learning indices of the male offspring was
evaluated using MWM.
Results: Our results showed that the traveled distance to locate on hidden platform in target quadrant and latency to
find the hidden platform were decreased significantly in offspring of REM sleep deprived and sham animals (P<0.05).
Conclusion: Based on our results, it seems that, applied range of stress which is executed through the sleep
deprivation could cause increase in spatial learning of adult male offspring rats.
Type of Manuscript: Experimental research article |
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