Volume 6, Issue 1 (Spring and Summer 2002)                   Physiol Pharmacol 2002, 6(1): 21-26 | Back to browse issues page

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Effect of reversible inactivation of locus ceruleus on naloxone-induced withdrawal syndrome in paragigantocellular neurons in morphine-dependent rats. Physiol Pharmacol 2002; 6 (1) :21-26
URL: http://ppj.phypha.ir/article-1-392-en.html
Effect of reversible inactivation of locus ceruleus on naloxone-induced withdrawal syndrome in paragigantocellular neurons in morphine-dependent rats
Abstract:   (10586 Views)
In this study, the effect of reversible inactivation of locus ceruleus (LC) on naloxone- induced withdrawal syndrome in paragigantocellular (PGi) neurons in morphine- dependent rats was investigated. For inactivation of LC, 1 µl of lidocaine (2%) was used and for induction of withdrawal syndrome, naloxone hydrochloride (2 mg/kg) was injected systemically. The results showed that in dependent group with intact LC, PGi single unit activity increased following naloxone administration, whereas in dependent group with inactivated LC, the observed increase was not significant.
Keywords: Paragigantocellular nucleus; Locus ceruleus; Morphine dependence; Withdrawal syndrome; Functional inactivation
     
Type of Manuscript: Experimental research article |
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