Volume 14, Issue 2 (Summer 2010)
Physiol Pharmacol 2010, 14(2): 127-136 |
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khori V, alizadeh F, aminosariyeh S, pourabouk M, nayebpour M, salehi A, et al . Protective effects of simvastatin on atrioventricular node during simulated experimental atrial fibrillation in vitro. Physiol Pharmacol 2010; 14 (2) :127-136
URL: http://ppj.phypha.ir/article-1-585-en.html
URL: http://ppj.phypha.ir/article-1-585-en.html
Vahid Khori 
, Fatemeh Alizadeh , Sorosh Aminosariyeh , Mona Pourabouk , Mohsen Nayebpour , Aref Salehi , Ahmadali Shirafkan , Saeid Saleki , Fakhri Badaghabadi , Ali Davariyan
, Fatemeh Alizadeh , Sorosh Aminosariyeh , Mona Pourabouk , Mohsen Nayebpour , Aref Salehi , Ahmadali Shirafkan , Saeid Saleki , Fakhri Badaghabadi , Ali Davariyan
Abstract: (11681 Views)
Introduction: Recent evidence has indicated that statins can reduce the incidence of both supraventricular and
ventricular arrhythmias with various mechanisms. The primary goal of the present study was to determine direct
protective role of simvastatin in modifying concealed conduction and the zone of concealment in a simulated model of
atrial fibrillation (AF) in an isolated atrioventricular (AV) node in rabbits.
Methods: Male Newsland rabbits (1.5-2 kg) were used in all experiments. Stimulating protocols (recovery, AF,
zone of concealment) were used to study electrophysiological properties of the node in one group (N=8). All of the
stimulated protocols were repeated in the presence and absence of different doses of simvastatin (0.5-10 μm). Results
were shown as mean ± S.E.
Results: Significant inhibition of the basic properties of the AV node was observed after the addition of simvastatin.
Significant prolongation of Wenkebakh index (wbcl) from 138.7±5.6 to 182.1±6.9 and functional refractory period
(FRP) from 157.7±5.9 to 182.1±6 msec at the concentration of 10 μM was observed. Maximum efficacy of simvastatin
in atrial fibrillation (AF) protocol was observed at the concentration of 3.10 μM, that was accompanied with prolonged
HH interval and increased number of concealed beats. Zone of concealment significantly increased at the concentrations
of 1.3 and 10 μM.
Conclusion: This study shows the protective effect of simvastatin in the prolongation of ventricular beats during
atrial fibrillation. The effect of simvastatin in increasing AV-nodal refractory period and zone of concealment are
probably the anti-arrhythmic mechanisms of this drug.
Type of Manuscript: Experimental research article |
Subject:
Pharmacokinetics/Dynamics
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