Volume 11, Issue 4 (Winter 2008)
Physiol Pharmacol 2008, 11(4): 300-305 |
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Gholamhassan V, Fereidoni M, Etemadi L, Sabzali M. Central administration of Peganum harmala seeds methanolic extract increases fear behavior in rats. Physiol Pharmacol 2008; 11 (4) :300-305
URL: http://ppj.phypha.ir/article-1-69-en.html
URL: http://ppj.phypha.ir/article-1-69-en.html
Abstract: (12377 Views)
Traditionally, Peganum harmala seeds (P.h) have been extensively used in the Asia region. We have
previously reported the increase of fear behavior by systemic administration of P.h extract. Here, we evaluated the
effect of central administration of the extract on the fear behavior.
Method: Methanolic extract of the plant's seeds (37% humidity) was prepared for the investigation. Elevated plusmaze
apparatus was used for evaluating the fear behavior. Adult male rats were categorized in 7 main groups (n=6). 1)
Sham control (saline 1 ul/rat, i.c.v) 2) Harmaline treated group (50 ug/rat, i.c.v). 3) Extract treated groups (10, 20, 25,
50, 100 ug/rat i.c.v respectively).
Results: All the doses of the P.h Methanolic extract as like as harmaline caused fear behavior (p<0.05). There was
no significant difference between the effects of harmaline and the doses of the plant extract.
Discusion: Overall, it is possible that the main alkaloid of the P.h (harmaline) is responsible for the increasing of
fear behavior. The effect seems to be done trough the central nervous system neurochemical mechanisms.
Type of Manuscript: Experimental research article |
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