Volume 15, Issue 2 (Summer 2011)
Physiol Pharmacol 2011, 15(2): 201-209 |
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Jafarzadeh Shirazi M R, Tamadon A, Namavar M R. Coexpression of gonadotropin inhibitory hormone with Agouti-related peptide in the neurons of arcuate nucleus of ewe hypothalamus. Physiol Pharmacol 2011; 15 (2) :201-209
URL: http://ppj.phypha.ir/article-1-691-en.html
URL: http://ppj.phypha.ir/article-1-691-en.html
Abstract: (16919 Views)
Introduction: Gonadotropin inhibitory hormone (GnIH) and Agouti-related peptide (AgRP) are orexigenic peptides
expressed in the arcuate nucleus (Arc) of the hypothalamus in the ewe. In addition, effects of GnIH and AgRP on the
regulation of gonadotropin releasing hormone secretion have been shown in some mammals. The objective of the
present study was to investigate the coexpression of GnIH and AgRP in Arc of the ewe hypothalamus.
Methods: Nine ewes were divided into follicular, luteal, and ovariectomised groups (n = 3 each group) and the
number of neurons that express GnIH and AgRP and the percentage of coexpression of these two peptides in the Arc of
each group was estimated by using immunohistochemistry.
Results: In different ovarian conditions of ewes, 19 to 32 percent of GnIH and AgRP neurons were coexpressed in
the Arc of the hypothalamus.
Conclusion: Results of the present study showed a possible cooperative role of AgRP and GnIH in the Arc of the
hypothalamus in regulation of ovarian function in ewe.
Type of Manuscript: Experimental research article |
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