Volume 15, Issue 4 (Winter 2012)                   Physiol Pharmacol 2012, 15(4): 507-516 | Back to browse issues page

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Khori V, Naeimipour S, Alizadeh A, Haeri Rouhani A, Pourabouk M, Badaghabadi F, et al . Acute direct effects of cyclosporine on extracellular field potential of isolated rabbit AV node during experimental atrial fibrillation. Physiol Pharmacol 2012; 15 (4) :507-516
URL: http://ppj.phypha.ir/article-1-741-en.html
Acute direct effects of cyclosporine on extracellular field potential of isolated rabbit AV node during experimental atrial fibrillation
Vahid Khori , Samaneh Naeimipour , Alimohammad Alizadeh , Ali Haeri Rouhani , Mona Pourabouk , Fakhri Badaghabadi , Maryam Rajaei , Sepideh Shariatnezhad , Hamidreza Moheimani , Saeed Saleki , Mohammad Ali Zeyghami , Mohsen Nayebpour
Abstract:   (10665 Views)
Introduction: Previous studies have indicated a relationship between MPTP pore and AV nodal rate-dependent properties. The aim of present study was to determine acute direct effects of cyclosporine on extracellular field potential of isolated rabbit AV node during experimental atrial fibrillation. Methods: In one group of male New Zealand rabbits (1.5-2.5 kg) cumulative concentrations of cyclosporine (0.5 – 10 m) were applied on isolated perfused atrio-nodal preparation (n=7). Extracellular field potential recording was sampled during specific stimulation protocols (recovery, zone of concealment and atrial fibrillation) in the presence of drug on electrophysiological properties of AV-node. Results: Cyclosporine significantly decreased the ventricular rate (HH mean) from 231.8 ± 5.7 to 277.4 ± 14.6 msec and functional refractory period during AF (AF FRP) from 138.3 ± 7.5 to 161.2 ± 10.31 msec in control and treated groups, respectively. Effective refractory period during AF (AF ERP) was significantly decreased by cyclosporine 10 mM compared to control group (p<0.05). Conclusion: Cyclosporine-evoked slowing ventricular heart rate during AF was induced by increasing functional refractoy period and ZOC. A possible mechanism can be through blocking of MPT pores.
Keywords: Atrio-ventricular node, Cyclosporine, mitochondrial permeability transitional pores, atrial fibrillation
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Type of Manuscript: Experimental research article | Subject: Pharmacokinetics/Dynamics
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