Volume 16, Issue 1 (Spring 2012)
Physiol Pharmacol 2012, 16(1): 79-85 |
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Hassanvand T, Balooch M, Azarnia M, Zardooz H, Erfani M, Hosseini S Y et al . Alterations in dopamine related behavior of the offspring of pregnant Wistar rats exposed to noise pollution stress. Physiol Pharmacol 2012; 16 (1) :79-85
URL: http://ppj.phypha.ir/article-1-805-en.html
URL: http://ppj.phypha.ir/article-1-805-en.html
Tayebeh Hassanvand 
, Mohammad Balooch , Mahnaz Azarnia , Homeira Zardooz , Marjan Erfani , Seyedeh Yassaman Hosseini , Hedayat Sahraei
, Mohammad Balooch , Mahnaz Azarnia , Homeira Zardooz , Marjan Erfani , Seyedeh Yassaman Hosseini , Hedayat Sahraei
Abstract: (10895 Views)
Introduction: Effects of stress on nervous system activity and development are well defined. In the present study,
the effects of maternal stress on dopamine-related behavior in the offspring were studied.
Methods: Female pregnant Wistar rats (200 g) were randomly exposed to the noise pollution stress (125 db) for 14
days (5 min/day). The time of exposure was random in order to avoid adaptation. The offspring were nursed by their
mothers until the adolescence (200 g-3 mounts of age). These animals were examined for their seeking behavior
including rearing, sniffing and locomotion using open field method. Twenty four hours later, they received
subcutaneous administration of the dopamine D2 receptor antagonist, sulpiride (5 mg/kg) for evaluation of dopamine
receptor sensitization.
Results: Our results showed that sniffing was reduced (P<0.01), but both rearing (P<0.05) and locomotion
(statically non significant) activity in the F2 of stress group was increased. Injection of sulpiride reduced animals
activity (sniffing, rearing and locomotion) in both groups but the reduction was more pronounced in the stress group
(P<0.001).
Conclusion: It could be concluded that dopamine-related behavior differed in the experimental group, which was
exposed to stress during intra-uterine life. In addition, the experimental group showed a pronounced response to
sulpiride, which may be due to alteration in brain dopamine system activity in these animals.
Type of Manuscript: Experimental research article |
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