Volume 19, Issue 2 (June 2015 2015)                   Physiol Pharmacol 2015, 19(2): 107-113 | Back to browse issues page

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Plotnikov E, Korotkova E, Voronova O, Dorozhko E, Bohan N, Plotnikov S. Lithium-based antioxidants: electrochemical properties and influence on immune cells. Physiol Pharmacol 2015; 19 (2) :107-113
URL: http://ppj.phypha.ir/article-1-1098-en.html
Lithium-based antioxidants: electrochemical properties and influence on immune cells
Evgenii Plotnikov , Elena Korotkova , Olesya Voronova , Elena Dorozhko , Nikolay Bohan , Sergey Plotnikov
Abstract:   (5058 Views)
Introduction: Lithium salts are known as effective psychotropic medicine for treatment bipolar disorder and may be used to treat alcoholism, schizoaffective disorders, and cluster headaches. The antioxidant activity and immunomodulatory effects of prospective lithium compounds have been investigated in this work. Materials and Methods: The antioxidant properties were studied by the voltammetry method. Influence of the lithium compounds on the immune cells of human blood were determined by measuring phagocytic activity of leucocytes and by the rate of blastic transformation of lymphocytes. Results: Relatively better antioxidant and immunotropic properties have been revealed for lithium ascorbate, compare to widely used drug-lithium carbonate. Lithium aspartate revealed antioxidant activity, as well. Conclusion: Studied lithium salts can be considered as prospective psychotropic antioxidant with immunomodulatory effects. The combination of these properties significantly extends the potential medical applications of lithium salts.
Keywords: antioxidant activity, immunomodulatory effects, voltammetry, lithium ascorbate, lithium aspartate
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Type of Manuscript: Experimental research article | Subject: Pharmacokinetics/Dynamics
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