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Introduction: Consumption of fructose sweeteners as an alternative to high-calorie diets has been linked to a variety metabolic diseases through oxidative stress increase. The study investigated changes in testicular and ovarian functions following Omega-3 polyunsaturated fatty acid supplementation (PUFAs) in rats fed with High Fructose Diet (HFD). Methods: Forty Wistar rats were equally and randomly distributed into four groups. Each group was sub-grouped into into two (2) based on gender with equal number of animals. Group A assigned as control, while Groups B and C were administered HFD containing 10% and 20% v/v fructose solution respectively, and Group D rats were provided 20% v/v HFD and Omega-3 PUFAs. Results: After six weeks of consumption, HFD caused semen quality and gonadal reproductive hormones reductions, while increasing testicular and ovarian oxidative stress. Omega-3 PUFAs improved the semen quality, reproductive hormone concentrations and antioxidant defense system. Conclusions: Therefore HFD impairs gonadal function, however dietary supplementation of Omega-3 improved gonadal functions by augmenting the antioxidant defense mechanism.

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