Volume 28, Issue 3 (September 2024)                   Physiol Pharmacol 2024, 28(3): 282-294 | Back to browse issues page

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Ekhoye E, Agbonifo-Chijiokwu E, Nwangwa E. Omega-3 PUFAs counteracts high fructose diet-induced gonadal impairment via fortified antioxidant defense. Physiol Pharmacol 2024; 28 (3) : 5
URL: http://ppj.phypha.ir/article-1-1980-en.html
Omega-3 PUFAs counteracts high fructose diet-induced gonadal impairment via fortified antioxidant defense
Ehitare Ekhoye , Ejime Agbonifo-Chijiokwu , Eze Nwangwa
Abstract:   (1722 Views)

Introduction: The consumption of fructose sweeteners as an alternative to high-calorie diets has been linked to various metabolic diseases due to increased oxidative stress. This study investigated changes in testicular and ovarian functions following Omega-3 polyunsaturated fatty acid supplementation (ω-3 PUFAs) in rats fed a High Fructose Diet (HFD).
Methods: Forty Wistar rats were equally and randomly distributed into four groups. Each group was further subdivided by gender, with an equal number of animals in each sub-group. Group A assigned as control, while Groups B and C were administered HFD containing 10% and 20% v/v fructose solution, respectively. Group D rats were provided 20% v/v HFD and ω-3 PUFAs. 
Results: After six weeks of consumption, HFD resulted in reduced semen quality and gonadal reproductive hormone levels, while increasing testicular and ovarian oxidative stress. ω-3 PUFAs improved semen quality, reproductive hormone concentrations, and antioxidant defense system.
Conclusion: HFD impairs gonadal function, however, dietary supplementation with ω-3 PUFAs improves gonadal functions by enhancing the antioxidant defense mechanism.

Article number: 5
Keywords: High-fructose diet, Infertility, Omega-3, Ovary, Oxidative stress
Full-Text [PDF 1247 kb]   (141 Downloads)    
Type of Manuscript: Experimental research article | Subject: Endocrine Physiology/Pharmacology
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